ArticleGenome biology and evolution2020
Culture Volume Influences the Dynamics of Adaptation under Long-Term Stationary Phase.
Article in Genome biology and evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Non-canonical gene amplifications facilitate adaptive evolution in bacteria.Nature microbiology · 2026Article
- Pseudomonas putida Dynamics of Adaptation under Prolonged Resource Exhaustion.Genome biology and evolution · 2024Article
- Escherichia coli adaptation under prolonged resource exhaustion is characterized by extreme parallelism and frequent historical contingency.PLoS genetics · 2024Article
- Biogenic Synthesis of Photosensitive Magnesium Oxide Nanoparticles Using Citron Waste Peel Extract and Evaluation of Their Antibacterial and Anticarcinogenic Potential.Bioinorganic chemistry and applications · 2024Article
- Biochemical and genetic dissection of the RNA-binding surface of the FinO domain ofRNA (New York, N.Y.) · 2023Article
- Metabolic adaptation to consume butyrate under prolonged resource exhaustion.PLoS genetics · 2023Article
- Biochemical and genetic dissection of the RNA-binding surface of the FinO domain ofbioRxiv : the preprint server for biology · 2023Article
- Optimization of the growth conditions through response surface methodology and metabolomics for maximizing the auxin production byFrontiers in microbiology · 2023Article
- Article
- Rapid Adaptation Often Occurs through Mutations to the Most Highly Conserved Positions of the RNA Polymerase Core Enzyme.Genome biology and evolution · 2022Article
- Molecular Evolutionary Dynamics of Energy Limited Microorganisms.Molecular biology and evolution · 2021Article
- Microbial population dynamics and evolutionary outcomes under extreme energy limitation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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Authors and funding
5 authors.
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Abstract
Escherichia coli and many other bacterial species, which are incapable of sporulation, can nevertheless survive within resource exhausted media by entering a state termed long-term stationary phase (LTSP). We have previously shown that E. coli populations adapt genetically under LTSP in an extremely convergent manner. Here, we examine how the dynamics of LTSP genetic adaptation are influenced by varying a single parameter of the experiment-culture volume. We find that culture volume affects survival under LTSP, with viable counts decreasing as volumes increase. Across all volumes, mutations accumulate with time, and the majority of mutations accumulated demonstrate signals of being adaptive. However, positive selection appears to affect mutation accumulation more strongly at higher, compared with lower volumes. Finally, we find that several similar genes are likely involved in adaptation across volumes. However, the specific mutations within these genes that contribute to adaptation can vary in a consistent manner. Combined, our results demonstrate how varying a single parameter of an evolutionary experiment can substantially influence the dynamics of observed adaptation.
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