Evidence map›Paper›PMID 33283770›Full record

ArticleIndian journal of pharmacology

Low oxygen microenvironment and cardiovascular remodeling: Role of dual L/N.type Ca

Shrilaxmi Bagali, Savitri M Nerune, R Chandramouli Reddy, Saeed M Yendigeri, Bheemshetty S Patil, Akram A Naikwadi, Raghavendra V Kulkarni, Kusal K Das

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Shrilaxmi BagaliLaboratory of Vascular Physiology and Medicine, Department of Physiology, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, Karnataka, India.
Savitri M NeruneDepartment of Pathology, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, Karnataka, India.
R Chandramouli ReddyDepartment of Biochemistry, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, Karnataka, India.
Saeed M YendigeriDepartment of Pathology, Al-Ameen Medical College, Vijayapura, Karnataka, India.
Bheemshetty S PatilDepartment of Anatomy, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, Karnataka, India.
Akram A NaikwadiDepartment of Pharmacology, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, Karnataka, India.
Raghavendra V KulkarniDepartment of Pharmaceutics and Pharmaceutical Technology, BLDEA's SSM College of Pharmacy and Research Centre, Vijayapura, Karnataka, India.
Kusal K DasLaboratory of Vascular Physiology and Medicine, Department of Physiology, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, Karnataka, India.
Shri BM Patil Medical College · INAl-Ameen Medical College · INBLDE University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePatients exposed to chronic sustained hypoxia frequently develop cardiovascular disease risk factors to ultimately succumb to adverse cardiovascular events. In this context, the present study intends to assess the role of cilnidipine (Cil), a unique calcium channel blocker that blocks both L-type and N-type calcium channels, on cardiovascular pathophysiology in face of chronic sustained hypoxia exposure. MATERIALS AND

methodsThe study involved Wistar strain albino rats. The group-wise allocation of the experimental animals is as follows - Group 1, control (21% O RESULTS AND

conclusionThe results demonstrated altered cardiovascular hemodynamics, disturbed cardiovascular autonomic balance, increased levels of VEGF and NOS3, and decreased bioavailability of NO on exposure to chronic sustained hypoxia. The histopathological examination further pointed toward cardiovascular remodeling. Treatment with Cil ameliorated the cardiovascular remodeling and endothelial dysfunction induced by CH exposure, which may be due to its blocking actions on L/N-type of calcium channels, indicating the possible therapeutic role of Cil against CH-induced cardiovascular pathophysiology.

Indexed as

AnimalsCalcium Channel BlockersCalcium Channels, L-TypeCalcium Channels, N-TypeDihydropyridinesMaleNitric OxideNitric Oxide Synthase Type IIIOxygenRatsRats, WistarVascular Endothelial Growth Factor ACalcium Channel BlockersCalcium Channels, L-TypeCalcium Channels, N-TypecilnidipineDihydropyridinesNitric OxideNitric Oxide Synthase Type IIINos3 protein, ratOxygenVascular Endothelial Growth Factor Avascular endothelial growth factor A, ratCardiovascular histopathologycardiovascular remodelingchronic hypoxiacilnidipineheart rate variabilitynormalized wall index

Identifiers

PMID33283770
PMCPMC8025765
OpenAlexW3110978801

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.