Evidence map›Paper›PMID 33283769›Full record

Observational studyIndian journal of pharmacology

Presence of allele CYP3A4*16 does not have any bearing on carbamazepine-induced adverse drug reactions in North Indian people with epilepsy.

Vivek Kumar Garg, Manoj Kumar Goyal, Madhu Khullar, Biman Saikia, Bikash Medhi, Ajay Prakash, Nandita Prabhat, Naresh Tandyala, Karthik Vinay Mahesh, Parampreet S Kharbanda and 5 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Vivek Kumar GargDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Manoj Kumar GoyalDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Madhu KhullarDepartment of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Biman SaikiaDepartment of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Bikash MedhiDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Ajay PrakashDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Nandita PrabhatDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Naresh TandyalaDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Karthik Vinay MaheshDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Parampreet S KharbandaDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Sudesh PrabhakarDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Manish ModiDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Vivek LalDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Ritu ShreeDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Julie SachdevaDepartment of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Post Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe objectives of this study were to determine the relationship between genetic polymorphisms in gene encodings for CYP3A4 and carbamazepine (CBZ)-induced dose-related side effects in North Indian people with epilepsy. PATIENTS AND

methodsThe current prospective study included 37 patients with CBZ-induced dose-related side effects and 102 patients who did not experience side effects while on CBZ. The genotyping for CYP3A4 allele (CYP3A4*16) was done using real-time polymerase chain reaction (RT-PCR) in Applied Biosystems 7500 RT-PCR System (USA). CBZ was administered in all patients at a dose varying from 15 to 20 mg/kg daily.

resultsVarious demographic variables were comparable between the groups except that control of seizures was far better in controls. After testing, it was found that none of our patients had the presence of CYP3A4*16 allele.

conclusionCYP3A4*16 allele is not represented significantly in North Indian people with CBZ-induced dose-related side effects.

Indexed as

AdolescentAdultAllelesAnticonvulsantsCarbamazepineCytochrome P-450 CYP3ADose-Response Relationship, DrugEpilepsyFemaleHumansIndiaMalePolymorphism, GeneticProspective StudiesYoung AdultAnticonvulsantsCarbamazepineCYP3A4 protein, humanCytochrome P-450 CYP3ACarbamazepineCYP3A4dose-related side effectsepilepsy

Identifiers

PMID33283769
PMCPMC8025771
OpenAlexW3112720520

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.