Evidence map›Paper›PMID 33283623›Full record

ArticleCell cycle (Georgetown, Tex.)2020

Combined use of microwave ablation and cell immunotherapy induces nonspecific immunity of hepatocellular carcinoma model mice.

Xuhua Duan, Manzhou Wang, Xinwei Han, Jianzhuang Ren, Guohao Huang, Shuguang Ju, Qinghui Zhang

Open access · greenAbstract read
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
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  7. Preclinical study of TLR stimulation combined PD-1 antibody enhance the therapeutic effect of microwave ablation on NSCLC.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
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  8. Review
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  20. Microwave ablation induces abscopal effectFrontiers in oncology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xuhua DuanDepartment of Interventional Radiology, the First Affiliated Hospital, Zhengzhou University , Zhengzhou, Henan Province, China.
Manzhou WangDepartment of Interventional Radiology, the First Affiliated Hospital, Zhengzhou University , Zhengzhou, Henan Province, China.
Xinwei HanDepartment of Interventional Radiology, the First Affiliated Hospital, Zhengzhou University , Zhengzhou, Henan Province, China.
Jianzhuang RenDepartment of Interventional Radiology, the First Affiliated Hospital, Zhengzhou University , Zhengzhou, Henan Province, China.
Guohao HuangDepartment of Interventional Radiology, the First Affiliated Hospital, Zhengzhou University , Zhengzhou, Henan Province, China.
Shuguang JuDepartment of Interventional Radiology, the First Affiliated Hospital, Zhengzhou University , Zhengzhou, Henan Province, China.
Qinghui ZhangDepartment of Interventional Radiology, the First Affiliated Hospital, Zhengzhou University , Zhengzhou, Henan Province, China.
First Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microwave ablation (MWA) has been widely used in the treatment of solid tumors. Studies have been less conducted on the efficacy of MWA used with cell immunotherapy in treating hepatocellular carcinoma (HCC). The current study aimed at exploring the efficacy of MWA in combination with cell immunotherapy in treating HCC. Hepa1-6 HCC mice were treated by MWA, blockade, or the combined therapy (MWA used with blockade), or left untreated. Survival rates of the mice were plotted by Kaplan-Meier Curve, followed by log-rank test. 25 days after the operation, surviving mice were monitored for tumor recurrence, and tumor volumes were calculated every 5 days. Immunohistochemistry and flow cytometry were performed to detect the numbers of CD4

Indexed as

AnimalsCarcinoma, HepatocellularCombined Modality TherapyCTLA-4 AntigenCytokinesDisease Models, AnimalImmune Checkpoint InhibitorsImmunityImmunotherapyLiver NeoplasmsMiceMice, Inbred BALB CMice, NudeMicrowavesProgrammed Cell Death 1 ReceptorRadiofrequency TherapyCTLA-4 AntigenCtla4 protein, mouseCytokinesImmune Checkpoint InhibitorsPdcd1 protein, mouseProgrammed Cell Death 1 Receptorcell immunotherapycombination therapyhepatocellular carcinomaMicrowave ablationnonspecific immunity

Identifiers

PMID33283623
PMCPMC7781627
OpenAlexW3112781056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.