Evidence map›Paper›PMID 33283328›Full record

ArticleJournal of clinical laboratory analysis2021

Interpretation of the HLA epitopes-Continuous dilution method for detection of high-titer IgG HLA antibody.

Yanli Xiao, Wei Liu, Zhongyu Kang, Daihong Li

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yanli XiaoDepartment of Blood Transfusion, Tianjin First Central Hospital, Tianjin, China.ORCID https://orcid.org/0000-0002-9193-8541
Wei LiuDepartment of Blood Transfusion, Tianjin First Central Hospital, Tianjin, China.
Zhongyu KangDepartment of Blood Transfusion, Tianjin First Central Hospital, Tianjin, China.ORCID https://orcid.org/0000-0002-6855-8153
Daihong LiDepartment of Blood Transfusion, Tianjin First Central Hospital, Tianjin, China.
Tianjin First Center Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe presence or absence of human leukocyte antigen (HLA) antibodies, especially the strength of donor-specific HLA antibodies (DSAs), has important roles in clinical evaluation and diagnostic decision-making for solid-organ transplantation. Dilution patterns help to give a new sight of HLA epitopes. "Epitope matching" is likely to lower the risk of developing DSA and increase the likelihood of matching a compatible donor.

methodsWe collected data evaluating HLA antibodies with a titration study using mean fluorescence intensity.

resultsDiluting the serum of recipients can reduce potential inhibitory effects, accurately evaluate the intensity of donor-specific HLA antibodies, and guide surgeons to take or not take intervention measures. Dilution patterns also help to give a new sight of HLA epitopes.

conclusionWe believe that from the viewpoint of HLA antibodies, the dilution model can provide new tools and insights for the study of HLA epitopes.

Indexed as

AllograftsEpitopesHistocompatibility TestingHLA AntigensHLA-DQ AntigensHumansImmunoglobulin GKidney TransplantationMaleMiddle AgedTissue DonorsEpitopesHLA AntigensHLA-DQ AntigensImmunoglobulin Gdonor-specific HLA antibodiesepitopetitration study

Identifiers

PMID33283328
PMCPMC7891501
OpenAlexW3108486116

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.