Evidence map›Paper›PMID 33283205›Full record

ArticleAging pathobiology and therapeutics2020

Development of a Geropathology Grading Platform for nonhuman primates.

Katie J Olstad, Denise M Imai, Rebekah I Keesler, Rachel Reader, John H Morrison, Jeffery A Roberts, John P Capitanio, Elizabeth S Didier, Marcelo J Kuroda, Heather Simmons and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging pathobiology and therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. The geropathology of organ-specific aging.Journal of translational science · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Katie J OlstadCalifornia National Primate Research Center, University of California, Davis, CA, USA.
Denise M ImaiComparative Pathology Laboratory, University of California, Davis, CA, USA.
Rebekah I KeeslerCalifornia National Primate Research Center, University of California, Davis, CA, USA.
Rachel ReaderCalifornia National Primate Research Center, University of California, Davis, CA, USA.
John H MorrisonCalifornia National Primate Research Center, University of California, Davis, CA, USA.
Jeffery A RobertsCalifornia National Primate Research Center, University of California, Davis, CA, USA.
John P CapitanioCalifornia National Primate Research Center, University of California, Davis, CA, USA.
Elizabeth S DidierCalifornia National Primate Research Center, University of California, Davis, CA, USA.
Marcelo J KurodaCalifornia National Primate Research Center, University of California, Davis, CA, USA.
Heather SimmonsWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Shabnam SalimiSchool of Medicine, University of Maryland, Baltimore, MD, USA.
Julie A MattisonTranslational Gerontology Branch, National Institute on Aging, NIH, Dickerson, MD, USA.
Yuji IkenoBarshop Institute for Longevity and Aging Studies and Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Warren LadigesDepartment of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA, USA.

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JAMES FLOYD NELSON · 1995 to 2026
$30.6M
Pathology of Aging Research NetworkR24AG047115 · NIA · UNIVERSITY OF WASHINGTON · PI LADIGES, WARREN C · 2014 to 2016
$1.1M
DNA methylation markers of Multimorbidity in Aging Humans and MiceK01AG059898 · NIA · UNIVERSITY OF WASHINGTON · PI SALIMI, SHABNAM · 2019 to 2023
$613k
NIA NIH HHS K01 AG059898NIA NIH HHS P30 AG013319NIA NIH HHS R24 AG047115NIH HHS P51 OD011106
6 · The paper itself

Abstract

A geropathology grading platform (GGP) for assessing age-related lesions has been established and validated for in inbred strain of mice. Because nonhuman primates (NHPs) share significant similarities in aging and spontaneous chronic diseases with humans, they provide excellent translational value for correlating histopathology with biological and pathological events associated with increasing age. Descriptive age-associated pathology has been described for rhesus macaques and marmosets, but a grading platform similar to the mouse GGP does not exist. The value of these NHP models is enhanced by considerable historical data from clinical, bio-behavioral, and social domains that align with health span in these animals. Successful adaptation of the mouse GGP for NHPs will include 1) expanding the range of organs examined; 2) standardizing necropsy collection, tissue trimming, and descriptive lesion terminology; 3) expanding beyond rhesus macaques and marmosets to include other commonly used NHPs in research; and 4) creating a national resource for age-related pathology to complement the extensive in-life datasets. Adaptation of the GGP to include translational models other than mice will be crucial to advance geropathology designed to enhance aging research.

Indexed as

age-related diseasesAginggeropathologygerosciencemarmosetsmicenonhuman primatesrhesus macaques

Identifiers

PMID33283205
PMCPMC7717498

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.