Evidence map›Paper›PMID 33283184›Full record

ArticleCerebral cortex communications2020

Corticostriatal Projections of Macaque Area 44.

Cole Korponay, Eun Young Choi, Suzanne N Haber

Open access · hybridAbstract read
In one paragraph

Article in Cerebral cortex communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Human striatal population state dynamics.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. Human striatal association megaclusters.Journal of neurophysiology · 2024
    Article
  6. Human Striatal Association Megaclusters.bioRxiv : the preprint server for biology · 2023
    Article
  7. Article
  8. Snapping Out of Autopilot: Overriding Habits in Real Time and the Role of Ventrolateral Prefrontal Cortex.Perspectives on psychological science : a journal of the Association for Psychological Science · 2023
    Article
  9. Article
  10. Misconfigured striatal connectivity profiles in smokers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  11. Laterality Hotspots in the Striatum.Cerebral cortex (New York, N.Y. : 1991) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Cole KorponayBasic Neuroscience Division, McLean Hospital, Belmont, MA 02478, USA.
Eun Young ChoiDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Suzanne N HaberBasic Neuroscience Division, McLean Hospital, Belmont, MA 02478, USA.
Harvard University · USMcLean Hospital · USStanford University · US

Funding

Continuity of the Limbic Circuit Through the Basal GangliaR01MH045573 · NIMH · UNIVERSITY OF ROCHESTER · PI HABER, SUZANNE N · 1989 to 2024
$10.1M
Neurocircuitry underlying goal-directed and habitual behavior: implications for substance use disorderF32DA048580 · NIDA · MCLEAN HOSPITAL · PI KORPONAY, COLE H · 2019 to 2021
$198k
NIDA NIH HHS F32 DA048580NIMH NIH HHS R01 MH045573
6 · The paper itself

Abstract

Ventrolateral frontal area 44 is implicated in inhibitory motor functions and facilitating prefrontal control over vocalization. The contribution of corticostriatal circuits to area 44 functions is unclear, as prior investigation of area 44 projections to the striatum-a central structure in motor circuits-is limited. Here, we used anterograde and retrograde tracing in macaques to map the innervation zone of area 44 corticostriatal projections, quantify their strengths, and evaluate their convergence with corticostriatal projections from other frontal cortical regions. First, whereas terminal fields from a rostral area 44 injection site were found primarily in the central caudate nucleus, those from a caudal area 44 injection site were found primarily in the ventrolateral putamen. Second, amongst sampled injection sites, area 44 input as a percentage of total frontal cortical input was highest in the ventral putamen at the level of the anterior commissure. Third, area 44 projections converged with orofacial premotor area 6VR and other motor-related projections (in the putamen), and with nonmotor prefrontal projections (in the caudate nucleus). Findings support the role of area 44 as an interface between motor and nonmotor functional domains, possibly facilitated by rostral and caudal area 44 subregions with distinct corticostriatal connectivity profiles.

Indexed as

area 44area 6VRcircuitryfrontostriatalneuroanatomyorofacial motor controltract-tracing

Identifiers

PMID33283184
PMCPMC7699020
OpenAlexW3096559402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.