ReviewMayo Clinic proceedings. Innovations, quality & outcomes2020
Takotsubo Syndrome: Cardiotoxic Stress in the COVID Era.
Review in Mayo Clinic proceedings. Innovations, quality & outcomes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Oxidative Stress in Takotsubo Syndrome: Insights into Extracellular Vesicles and Their Potential Clinical Relevance.Antioxidants (Basel, Switzerland) · 2026Review
- [Rare cases of stress cardiomyopathy triggered by pulmonary embolism and reverse Takotsubo].Revista medica del Instituto Mexicano del Seguro Social · 2026Article
- When a Woman's Heart Fails to Contain: Takotsubo Syndrome as a Gendered Collapse of Emotional Regulation.Life (Basel, Switzerland) · 2025Review
- Epidemiology, Pathophysiology, Diagnosis, and Principles of Management of Takotsubo Cardiomyopathy: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2023Review
- Takotsubo Cardiomyopathy as a Cardiovascular Manifestation of COVID-19: A Case Report and Literature Review.Cureus · 2022Article
- Myocardial Ischemia in Patients with COVID-19 Infection: Between Pathophysiological Mechanisms and Electrocardiographic Findings.Life (Basel, Switzerland) · 2022Review
- Update of Takotsubo cardiomyopathy: Present experience and outlook for the future.International journal of cardiology. Heart & vasculature · 2022Review
- Post-COVID-19 Syndrome: Involvement and Interactions between Respiratory, Cardiovascular and Nervous Systems.Journal of clinical medicine · 2022Review
- The Impact of COVID-19 on Nuclear Medicine Operations Including Cardiovascular Manifestations in the USA.Seminars in nuclear medicine · 2022Review
- Mortality Correlates in Patients With Takotsubo Syndrome During the COVID-19 Pandemic.Mayo Clinic proceedings. Innovations, quality & outcomes · 2021Article
- COVID 19: A Stressor for Both the Patient and the Anesthesiologist.Journal of cardiothoracic and vascular anesthesia · 2021Article
- A systematic review of biomarkers in Takotsubo syndrome: A focus on better understanding the pathophysiology.International journal of cardiology. Heart & vasculature · 2021Review
- Impact of COVID-19 in patients hospitalized with stress cardiomyopathy: A nationwide analysis.Progress in cardiovascular diseasesArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Takotsubo syndrome (TTS), also known as stress cardiomyopathy and broken heart syndrome, is a neurocardiac condition that is among the most dramatic manifestations of psychosomatic disorders. This paper is based on a systematic review of TTS and stress cardiomyopathy using a PubMed literature search. Typically, an episode of severe emotional or physical stress precipitates regions of left ventricular hypokinesis or akinesis, which are not aligned with a coronary artery distribution and are out of proportion to the modest troponin leak. A classic patient with TTS is described; one who had chest pain and dyspnea while watching an anxiety-provoking evening news program on the coronavirus disease 2019 (COVID-19) pandemic. An increase in the incidence of TTS appears to be a consequence of the COVID-19 pandemic, with the TTS incidence rising 4.5-fold during the COVID-19 pandemic even in individuals without severe acute respiratory syndrome coronavirus 2 infection. Takotsubo syndrome is often mistaken for acute coronary syndrome because they both typically present with chest pain, electrocardiographic changes suggesting myocardial injury/ischemia, and troponin elevations. Recent studies report that the prognosis for TTS is similar to that for acute myocardial infarction. This review is an update on the mechanisms underlying TTS, its diagnosis, and its optimal management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.