ArticleAlzheimer's & dementia (New York, N. Y.)2020
Differentiating among stages of cognitive impairment in aging: Version 3 of the Uniform Data Set (UDS) neuropsychological test battery and MoCA index scores.
Erratum issuedOpen access · goldAbstract read
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Article in Alzheimer's & dementia (New York, N. Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.
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34citing papers in PubMed
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34 citing papers in PubMed, 51 citations in OpenAlex.
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Corrections and comments
- Erratum issuedErratum.2021
Authors and funding
23 authors at 15 institutions in 1 country.
Hiroko H DodgeLayton Aging and Alzheimer's Disease Center Oregon Health & Science University Portland Oregon USA.
Felicia C GoldsteinGoizueta Alzheimer's Disease Research Center Emory University School of Medicine Atlanta Georgia USA.
Nicole I WakimDepartment of Biostatistics University of Michigan Ann Arbor Michigan USA.
Tamar GefenThe Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University Chicago Illinois USA.
Merilee TeylanNational Alzheimer's Coordinating Center University of Washington Seattle Washington USA.
Kwun C G ChanNational Alzheimer's Coordinating Center University of Washington Seattle Washington USA.
Walter A KukullNational Alzheimer's Coordinating Center University of Washington Seattle Washington USA.
Lisa L BarnesRush Alzheimer's Disease Center Rush University Medical Center Chicago Illinois USA.
Bruno GiordaniMichigan Alzheimer's Disease Center University of Michigan Ann Arbor Michigan USA.
Timothy M HughesThe Wake Forest Alzheimer's Disease Research Center, Wake Forest School of Medicine Winston-Salem North Carolina USA.
Joel H KramerMemory and Aging Center University of California San Francisco San Francisco California USA.
David A LoewensteinCenter for Cognitive Neuroscience and Aging University of Miami Miller School of Medicine Miami Florida USA.
Daniel C MarsonAlzheimer's Disease Center University of Alabama at Birmingham Birmingham Alabama USA.
Dan M MungasThe UC Davis Alzheimer's Disease Research Center University of California, Davis Sacramento California USA.
Nora MattekLayton Aging and Alzheimer's Disease Center Oregon Health & Science University Portland Oregon USA.
Bonnie C SachsThe Wake Forest Alzheimer's Disease Research Center, Wake Forest School of Medicine Winston-Salem North Carolina USA.
David P SalmonThe Shiley-Marcos Alzheimer's Disease Research Center University of California, San Diego La Jolla California USA.
Monica Willis-ParkerGoizueta Alzheimer's Disease Research Center Emory University School of Medicine Atlanta Georgia USA.
Kathleen A Welsh-BohmerAlzheimer's Disease Research Center Duke University Durham North Carolina USA.
Katherine V WildLayton Aging and Alzheimer's Disease Center Oregon Health & Science University Portland Oregon USA.
John C MorrisKnight Alzheimer Disease Research Center Washington University School of Medicine St. Louis Missouri USA.
Sandra WeintraubThe Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University Chicago Illinois USA.
National Alzheimer's Coordinating Center (NACC)
Oregon Health & Science University · USUniversity of Washington · USEmory University · USNorthwestern University · USWake Forest University · USAlzheimer’s Disease Neuroimaging Initiative · USDuke University · USMichigan United · USRush University Medical Center · USUniversity Memory and Aging Center · USUniversity of Alabama at Birmingham · USUniversity of California, Davis · USUniversity of Miami · USUniversity of Michigan–Ann Arbor · USWashington University in St. Louis · US
Funding
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8MTHERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI JAYADEY, SUMAN · 1985 to 2019
$57.2MVIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 1985 to 2018
$55.4MWASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1MSatellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DE JAGER, PHILIP L · 1989 to 2019
$46.3MNational Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8MTREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKER, JAMES T. · 1985 to 2019
$43.0MTHE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1MVASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARANDA, MARIA P. · 1985 to 2019
$41.0MVESICULAR LOCALIZATION AND FUNCTION OF PRESENILIN 1 FRAGMENTP50AG005138 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SCHIMMING, CORBETT · 1985 to 2019
$37.9M'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1985 to 2019
$37.6MNIA NIH HHS P30 AG008017NIA NIH HHS P30 AG008051NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG012300NIA NIH HHS P30 AG013846NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG028383NIA NIH HHS P30 AG035982NIA NIH HHS P30 AG049638NIA NIH HHS P30 AG053760NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG066511NIA NIH HHS P30 AG066518NIA NIH HHS P30 AG072976NIA NIH HHS P50 AG005131NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG005134NIA NIH HHS P50 AG005136NIA NIH HHS P50 AG005138NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG005146NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG008702NIA NIH HHS P50 AG016573NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG023501NIA NIH HHS P50 AG025688NIA NIH HHS P50 AG033514NIA NIH HHS P50 AG047266NIA NIH HHS P50 AG047270NIA NIH HHS P50 AG047366NIA NIH HHS R01 AG062566NIA NIH HHS U01 AG016976NIA NIH HHS U24 AG072122
Abstract
introductionFederally funded Alzheimer's Disease Centers in the United States have been using a standardized neuropsychological test battery as part of the National Alzheimer's Coordinating Center Uniform Data Set (UDS) since 2005. Version 3 (V3) of the UDS replaced the previous version (V2) in 2015. We compared V2 and V3 neuropsychological tests with respect to their ability to distinguish among the Clinical Dementia Rating (CDR) global scores of 0, 0.5, and 1.
methodsFirst, we matched participants receiving V2 tests (V2 cohort) and V3 tests (V3 cohort) in their cognitive functions using tests common to both versions. Then, we compared receiver-operating characteristic (ROC) area under the curve in differentiating CDRs for the remaining tests.
resultsSome V3 tests performed better than V2 tests in differentiating between CDR 0.5 and 0, but the improvement was limited to Caucasian participants. DISCUSSION: Further efforts to improve the ability for early identification of cognitive decline among diverse racial groups are required.
Indexed as
differentiating CDRNational Alzheimer's Coordinating Center Uniform Data Set (NACC UDS)optimal cut‐pointracial differencesreceiver‐operating characteristic area under the curve (ROC‐AUC)validity
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