Evidence map›Paper›PMID 33282952›Full record

ArticleBioMed research international2020

Macrophage Deficiency Makes Intestinal Epithelial Cells Susceptible to NSAID-Induced Damage.

Xinxin Wang, Jiayang Wang, Tianyu Xie, Shuo Li, Di Wu, Yixun Lu, Xin Guo, Lin Chen

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xinxin Wang *Department of General Surgery, Chinese PLA General Hospital, No. 28 Fuxing Rd. Beijing 100853, China.
Jiayang Wang *Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Tianyu XieDepartment of General Surgery, Chinese PLA General Hospital, No. 28 Fuxing Rd. Beijing 100853, China.
Shuo LiDepartment of General Surgery, Chinese PLA General Hospital, No. 28 Fuxing Rd. Beijing 100853, China.
Di WuDepartment of General Surgery, Chinese PLA General Hospital, No. 28 Fuxing Rd. Beijing 100853, China.
Yixun LuDepartment of General Surgery, Chinese PLA General Hospital, No. 28 Fuxing Rd. Beijing 100853, China.
Xin GuoDepartment of General Surgery, Chinese PLA General Hospital, No. 28 Fuxing Rd. Beijing 100853, China.
Lin ChenDepartment of General Surgery, Chinese PLA General Hospital, No. 28 Fuxing Rd. Beijing 100853, China.ORCID https://orcid.org/0000-0002-3957-1869
Chinese PLA General Hospital · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIn Crohn's disease (CD), the mechanisms underlying the regulation by granulocyte-macrophage colony-stimulating factor (GM-CSF) of mucosal barrier function in the ileum are unclear. We analyzed the molecular mechanisms underlying the regulation by GM-CSF of the mucosal barrier function.

methodsWe examined the role of GM-CSF in the intestinal barrier function in CD at the molecular-, cellular-, and animal-model levels.

resultsMacrophages directly secreted GM-CSF, promoting intestinal epithelial proliferation and inhibiting apoptosis, which maintained intestinal barrier function. Macrophages were absent in NSAID-induced ileitis, causing GM-CSF deficiency, increasing the apoptosis rate, decreasing the proliferation rate, increasing inter- and paracellular permeabilities, decreasing the TJP levels, and reducing the numbers of mesenteric lymph nodes, memory T cells, and regulatory T cells in Csf1

conclusionsGM-CSF is required for the maintenance of intestinal barrier function. Macrophages directly secrete GM-CSF, promoting intestinal epithelial proliferation and inhibiting apoptosis.

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalApoptosisBacterial TranslocationCaco-2 CellsCD4 AntigensCell Membrane PermeabilityCell MovementCell ProliferationEpithelial CellsForkhead Transcription FactorsGranulocyte-Macrophage Colony-Stimulating FactorHumansIntestinesKi-67 AntigenLymph NodesAnti-Inflammatory Agents, Non-SteroidalCD4 AntigensForkhead Transcription FactorsFoxp3 protein, mouseGranulocyte-Macrophage Colony-Stimulating FactorKi-67 AntigenPiroxicamTight Junction Proteins

Identifiers

PMID33282952
PMCPMC7685797
OpenAlexW3099296478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.