Evidence map›Paper›PMID 33282892›Full record

ArticleFrontiers in medicine2020

Characterization of Donor Variability for γδ T Cell

Rebecca E Burnham, Jaquelyn T Zoine, Jamie Y Story, Swetha N Garimalla, Greg Gibson, Aaron Rae, Erich Williams, Lisa Bixby, David Archer, Christopher B Doering and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
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  15. Arming Vδ2 T Cells with Chimeric Antigen Receptors to Combat Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Review
  16. Review
  17. Directing the migration of serum-free,Frontiers in immunology · 2024
    Article
  18. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Rebecca E BurnhamDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, United States.
Jaquelyn T ZoineDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, United States.
Jamie Y StoryDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, United States.
Swetha N GarimallaSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, United States.
Greg GibsonSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, United States.
Aaron RaeDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, United States.
Erich WilliamsDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, United States.
Lisa BixbyDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, United States.
David ArcherDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, United States.
Christopher B DoeringDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, United States.
H Trent SpencerDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, United States.
Center for Cancer and Blood Disorders · USEmory University · USGeorgia Institute of Technology · US

Funding

Exploiting chemoimmunotherapy strategies with genetically-engineered gd T cellsR21CA223300 · NCI · EMORY UNIVERSITY · PI GOLDSMITH, KELLY C, SPENCER, H TRENT · 2018 to 2019
$367k
NCI NIH HHS R21 CA223300
6 · The paper itself

Abstract

Gamma delta (γδ) T cells recently emerged as an attractive candidate for cancer immunotherapy treatments due to their inherent cytotoxicity against both hematological and solid tumors. Moreover, γδ T cells provide a platform for the development of allogeneic cell therapies, as they can recognize antigens independent of MHC recognition and without the requirement for a chimeric antigen receptor. However, γδ T cell adoptive cell therapy depends on

Indexed as

allogeneic cell productsex vivo expanded T cellsgamma delta (γδ) T cellsmixed cell productserum free expansion

Identifiers

PMID33282892
PMCPMC7691424
OpenAlexW3105483727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.