Evidence map›Paper›PMID 33282876›Full record

ReviewFrontiers in cell and developmental biology2020

Location, Location, Location: How Vascular Specialization Influences Hematopoietic Fates During Development.

Adam M Heck, Takashi Ishida, Brandon Hadland

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. 3DACS biomaterials science & engineering · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Functionalized 3D scaffolds for engineering the hematopoietic niche.Frontiers in bioengineering and biotechnology · 2022
    Review
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Adam M HeckClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Takashi IshidaClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Brandon HadlandClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Fred Hutch Cancer Center · USUniversity of Washington · US

Funding

Niche signals in HSC genesisRC2DK114777 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BERNSTEIN, IRWIN D, RAFII, SHAHIN · 2017 to 2021
$3.3M
Functional and transcriptional analysis of embryonic hematopoietic stem cell development at the single cell levelK08HL140143 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HADLAND, BRANDON K · 2018 to 2021
$584k
NHLBI NIH HHS K08 HL140143NIDDK NIH HHS RC2 DK114777
6 · The paper itself

Abstract

During embryonic development, sequential waves of hematopoiesis give rise to blood-forming cells with diverse lineage potentials and self-renewal properties. This process must accomplish two important yet divergent goals: the rapid generation of differentiated blood cells to meet the needs of the developing embryo and the production of a reservoir of hematopoietic stem cells to provide for life-long hematopoiesis in the adult. Vascular beds in distinct anatomical sites of extraembryonic tissues and the embryo proper provide the necessary conditions to support these divergent objectives, suggesting a critical role for specialized vascular niche cells in regulating disparate blood cell fates during development. In this review, we will examine the current understanding of how organ- and stage-specific vascular niche specialization contributes to the development of the hematopoietic system.

Indexed as

aorta gonad mesonephros regiondevelopmental hematopoiesisendothelial cellfetal liverhematopoietic stem cellhemogenic endotheliumvascular nichesyolk sac

Identifiers

PMID33282876
PMCPMC7691428
OpenAlexW3102058848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.