Evidence map›Paper›PMID 33282678›Full record

ArticleBrain plasticity (Amsterdam, Netherlands)2020

Diffusion tensor-MRI detects exercise-induced neuroplasticity in the hippocampal microstructure in mice.

Mohammad R Islam, Renhao Luo, Sophia Valaris, Erin B Haley, Hajime Takase, Yinching Iris Chen, Bradford C Dickerson, Karin Schon, Ken Arai, Christopher T Nguyen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain plasticity (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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  15. Repeatability of neurite orientation dispersion and density imaging in patients with traumatic brain injury.Journal of neuroimaging : official journal of the American Society of Neuroimaging
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mohammad R IslamCardiovascular Research Center, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA.
Renhao LuoCardiovascular Research Center, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA.
Sophia ValarisCardiovascular Research Center, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA.
Erin B HaleyCardiovascular Research Center, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA.
Hajime TakaseNeuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Yinching Iris ChenAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Bradford C DickersonAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Karin SchonDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.
Ken AraiNeuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Christopher T NguyenCardiovascular Research Center, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA.
Christiane D WrannCardiovascular Research Center, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, USA.

Funding

Serial evaluation of cardioprotective effects of exercise training in heart failure using cardiac diffusion tensor MRIR01HL151704 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NGUYEN, CHRISTOPHER T · 2020 to 2024
$3.4M
NHLBI NIH HHS R01 HL151704
6 · The paper itself

Abstract

backgroundDespite considerable research on exercise-induced neuroplasticity in the brain, a major ongoing challenge in translating findings from animal studies to humans is that clinical and preclinical settings employ very different techniques.

objectiveHere we aim to bridge this divide by using diffusion tensor imaging MRI (DTI), an advanced imaging technique commonly applied in human studies, in a longitudinal exercise study with mice.

methodsWild-type mice were exercised using voluntary free-wheel running, and MRI scans were at baseline and after four weeks and nine weeks of running.

resultsBoth hippocampal volume and fractional anisotropy, a surrogate for microstructural directionality, significantly increased with exercise. In addition, exercise levels correlated with effect size. Histological analysis showed more PDGFR

conclusionsThese results provide compelling

Indexed as

DTIexercisehippocampusMRIneuroplasticity

Identifiers

PMID33282678
PMCPMC7685674

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.