ArticleBiomedical optics express2020
Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging.
Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Optically bandlimited coherent lateral resampling for optical coherence tomography.Biomedical optics express · 2026Article
- Megahertz dynamic optical coherence tomography of blisters in human skin.Biomedical optics express · 2025Article
- Microscope integrated MHz optical coherence tomography system for neurosurgery: development and clinical in-vivo imaging.Biomedical optics express · 2024Article
- Advanced nanomaterials for imaging of eye diseases.ADMET & DMPK · 2024Review
- 828 kHz retinal imaging with an 840 nm Fourier domain mode locked laser.Biomedical optics express · 2023Article
- Continuous spectral zooming forBiomedical optics express · 2022Article
- Digital ocular swept source optical coherence aberrometry.Biomedical optics express · 2021Article
- Resolution-enhanced OCT and expanded framework of information capacity and resolution in coherent imaging.Scientific reports · 2021Article
- Compressive sensing for polarization sensitive optical coherence tomography.Journal of physics D: Applied physics · 2021Article
- Complex regression Doppler optical coherence tomography.Journal of biomedical optics · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to realize adjustable A-scan rates of fast optical coherence tomography (OCT) systems, we investigate averaging of OCT image data acquired with a MHz-OCT system based on a Fourier Domain Mode Locked (FDML) laser. Increased system sensitivity and image quality can be achieved with the same system at the cost of lower imaging speed. Effectively, the A-scan rate can be reduced in software by a freely selectable factor. We demonstrate a detailed technical layout of the strategies necessary to achieve efficient coherent averaging. Since there are many new challenges specific to coherent averaging in swept source MHz-OCT, we analyze them point by point and describe the appropriate solutions. We prove that coherent averaging is possible at MHz OCT-speed without special interferometer designs or digital phase stabilization. We find, that in our system up to ∼100x coherent averaging is possible while achieving a sensitivity increase close to the ideal values. This corresponds to a speed reduction from 3.3 MHz to 33 kHz and a sensitivity gain of 20 dB. We show an imaging comparison between coherent and magnitude averaging of a human finger knuckle joint in vivo with 121 dB sensitivity for the coherent case. Further, the benefits of computational downscaling in low sensitivity MHz-OCT systems are analyzed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.