Evidence map›Paper›PMID 33282508›Full record

ArticleBiomedical optics express2020

Towards detection of brain injury using multimodal non-invasive neuromonitoring in adults undergoing extracorporeal membrane oxygenation.

Irfaan A Dar, Imad R Khan, Ross K Maddox, Olga Selioutski, Kelly L Donohue, Mark A Marinescu, Sunil M Prasad, Nadim H Quazi, Jack S Donlon, Emily A Loose and 7 more

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Irfaan A DarDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14620, USA.
Imad R KhanDepartment of Neurology, Division of Neurocritical Care, University of Rochester Medical Center, Rochester, New York 14642, USA.
Ross K MaddoxDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14620, USA.
Olga SelioutskiDepartment of Neurology, Division of Epilepsy, University of Rochester Medical Center, Rochester, New York 14642, USA.
Kelly L DonohueDepartment of Neurology, Division of Neurocritical Care, University of Rochester Medical Center, Rochester, New York 14642, USA.
Mark A MarinescuDepartment of Medicine, Division of Cardiology, University of Rochester Medical Center, Rochester, New York 14642, USA.
Sunil M PrasadDepartment of Surgery, Division of Cardiac Surgery, University of Rochester Medical Center, Rochester, New York 14642, USA.
Nadim H QuaziDepartment of Biology, University of Rochester, Rochester, New York 14620, USA.
Jack S DonlonDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14620, USA.
Emily A LooseDepartment of Biology, University of Rochester, Rochester, New York 14620, USA.
Gabriel A RamirezDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14620, USA.
Jingxuan RenDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14620, USA.ORCID https://orcid.org/0000-0002-0020-1211
Joseph B MajeskiDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14620, USA.
Kenneth AbramsonDepartment of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Turgut DurduranICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels (Barcelona), 08860, Spain.ORCID https://orcid.org/0000-0001-5838-1027
David R BuschDepartment of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.ORCID https://orcid.org/0000-0002-9488-944X
Regine ChoeDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14620, USA.ORCID https://orcid.org/0000-0001-5851-4504
University of Rochester · USUniversity of Rochester Medical Center · USInstitució Catalana de Recerca i Estudis Avançats · ESThe University of Texas Southwestern Medical Center · USUniversity of Pennsylvania · US

Funding

Development of quantitative optical tools to continuously monitor cerebral autoregulation, blood flow, oxygenation and inflammation during pediatric extracorporeal life supportR01NS122119 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI David Richard Busch · 2022 to 2026
$3.2M
NINDS NIH HHS R01 NS122119
6 · The paper itself

Abstract

Extracorporeal membrane oxygenation (ECMO) is a form of cardiopulmonary bypass that provides life-saving support to critically ill patients whose illness is progressing despite maximal conventional support. Use in adults is expanding, however neurological injuries are common. Currently, the existing brain imaging tools are a snapshot in time and require high-risk patient transport. Here we assess the feasibility of measuring diffuse correlation spectroscopy, transcranial Doppler ultrasound, electroencephalography, and auditory brainstem responses at the bedside, and developing a cerebral autoregulation metric. We report preliminary results from two patients, demonstrating feasibility and laying the foundation for future studies monitoring neurological health during ECMO.

Identifiers

PMID33282508
PMCPMC7687959
OpenAlexW3091758218

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.