Evidence map›Paper›PMID 33282494›Full record

ArticleBiomedical optics express2020

Multi-meridian corneal imaging of air-puff induced deformation for improved detection of biomechanical abnormalities.

Andrea Curatolo, Judith S Birkenfeld, Eduardo Martinez-Enriquez, James A Germann, Geethika Muralidharan, Jesús Palací, Daniel Pascual, Ashkan Eliasy, Ahmed Abass, Jędrzej Solarski and 4 more

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
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  5. Review
  6. In vivo assessment of multifocal contact lens fitting using anterior segment optical coherence tomography.Contact lens & anterior eye : the journal of the British Contact Lens Association · 2025
    Article
  7. Article
  8. A Novel Approach to Fabricate Early Keratoconus Phantom Models.Translational vision science & technology · 2025
    Article
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  19. Computational and structural biotechnology journal · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 4 countries.

Andrea CuratoloInstituto de Óptica "Daza de Valdés", Consejo Superior de Investigaciones Científicas (IO, CSIC), Madrid, Spain.ORCID https://orcid.org/0000-0001-6855-0074
Judith S BirkenfeldInstituto de Óptica "Daza de Valdés", Consejo Superior de Investigaciones Científicas (IO, CSIC), Madrid, Spain.
Eduardo Martinez-EnriquezInstituto de Óptica "Daza de Valdés", Consejo Superior de Investigaciones Científicas (IO, CSIC), Madrid, Spain.
James A GermannInstituto de Óptica "Daza de Valdés", Consejo Superior de Investigaciones Científicas (IO, CSIC), Madrid, Spain.
Geethika MuralidharanInstituto de Óptica "Daza de Valdés", Consejo Superior de Investigaciones Científicas (IO, CSIC), Madrid, Spain.
Jesús Palací2EyesVision SL, Madrid, Spain.
Daniel PascualInstituto de Óptica "Daza de Valdés", Consejo Superior de Investigaciones Científicas (IO, CSIC), Madrid, Spain.
Ashkan EliasyBiomechanical Engineering Group, University of Liverpool, Liverpool, United Kingdom.
Ahmed AbassBiomechanical Engineering Group, University of Liverpool, Liverpool, United Kingdom.ORCID https://orcid.org/0000-0002-8622-4632
Jędrzej SolarskiPhysical Optics and Biophotonics Group, Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland.
Karol KarnowskiPhysical Optics and Biophotonics Group, Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland.ORCID https://orcid.org/0000-0002-5426-5878
Maciej WojtkowskiPhysical Optics and Biophotonics Group, Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland.
Ahmed ElsheikhBiomechanical Engineering Group, University of Liverpool, Liverpool, United Kingdom.
Susana MarcosInstituto de Óptica "Daza de Valdés", Consejo Superior de Investigaciones Científicas (IO, CSIC), Madrid, Spain.
Consejo Superior de Investigaciones Científicas · ESInstitute of Biochemistry and Biophysics, Polish Academy of Sciences · PLUniversity of Liverpool · GBMoorfields Eye Hospital NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Corneal biomechanics play a fundamental role in the genesis and progression of corneal pathologies, such as keratoconus; in corneal remodeling after corneal surgery; and in affecting the measurement accuracy of glaucoma biomarkers, such as the intraocular pressure (IOP). Air-puff induced corneal deformation imaging reveals information highlighting normal and pathological corneal response to a non-contact mechanical excitation. However, current commercial systems are limited to monitoring corneal deformation only on one corneal meridian. Here, we present a novel custom-developed swept-source optical coherence tomography (SSOCT) system, coupled with a collinear air-puff excitation, capable of acquiring dynamic corneal deformation on multiple meridians. Backed by numerical simulations of corneal deformations, we propose two different scan patterns, aided by low coil impedance galvanometric scan mirrors that permit an appropriate compromise between temporal and spatial sampling of the corneal deformation profiles. We customized the air-puff module to provide an unobstructed SSOCT field of view and different peak pressures, air-puff durations, and distances to the eye. We acquired multi-meridian corneal deformation profiles (a) in healthy human eyes

Identifiers

PMID33282494
PMCPMC7687933
OpenAlexW3084719532

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.