Evidence map›Paper›PMID 33282485›Full record

ArticleBiomedical optics express2020

Enrichment and ratiometric detection of circulating tumor cells using PSMA- and folate receptor-targeted magnetic and surface-enhanced Raman scattering nanoparticles.

Pradyumna Kedarisetti, Vincent R Bouvet, Wei Shi, Cody N Bergman, Jennifer Dufour, Afshin Kashani Ilkhechi, Kevan L Bell, Robert J Paproski, John D Lewis, Frank R Wuest and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Pradyumna KedarisettiDepartment of Electrical and Computer Engineering, University of Alberta, Edmonton, AB, T6G 1H9, Canada.ORCID https://orcid.org/0000-0002-2522-5535
Vincent R BouvetDepartment of Oncology, University of Alberta, Edmonton, AB, T6G 1Z2, Canada.
Wei ShiDepartment of Electrical and Computer Engineering, University of Alberta, Edmonton, AB, T6G 1H9, Canada.
Cody N BergmanDepartment of Oncology, University of Alberta, Edmonton, AB, T6G 1Z2, Canada.
Jennifer DufourDepartment of Oncology, University of Alberta, Edmonton, AB, T6G 1Z2, Canada.
Afshin Kashani IlkhechiDepartment of Electrical and Computer Engineering, University of Alberta, Edmonton, AB, T6G 1H9, Canada.
Kevan L BellDepartment of Electrical and Computer Engineering, University of Alberta, Edmonton, AB, T6G 1H9, Canada.ORCID https://orcid.org/0000-0002-5335-0704
Robert J PaproskiDepartment of Oncology, University of Alberta, Edmonton, AB, T6G 1Z2, Canada.
John D LewisDepartment of Oncology, University of Alberta, Edmonton, AB, T6G 1Z2, Canada.
Frank R WuestDepartment of Oncology, University of Alberta, Edmonton, AB, T6G 1Z2, Canada.
Roger J ZempDepartment of Electrical and Computer Engineering, University of Alberta, Edmonton, AB, T6G 1H9, Canada.ORCID https://orcid.org/0000-0001-6802-5624
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The presence of circulating tumor cells (CTCs) in a patient's bloodstream is a hallmark of metastatic cancer. The detection and analysis of CTCs is a promising diagnostic and prognostic strategy as they may carry useful genetic information from their derived primary tumor, and the enumeration of CTCs in the bloodstream has been known to scale with disease progression. However, the detection of CTCs is a highly challenging task owing to their sparse numbers in a background of billions of background blood cells. To effectively utilize CTCs, there is a need for an assay that can detect CTCs with high specificity and can locally enrich CTCs from a liquid biopsy. We demonstrate a versatile methodology that addresses these needs by utilizing a combination of nanoparticles. Enrichment is achieved using targeted magnetic nanoparticles and high specificity detection is achieved using a ratiometric detection approach utilizing multiplexed targeted and non-targeted surface-enhanced Raman Scattering Nanoparticles (SERS-NPs). We demonstrate this approach with model prostate and cervical circulating tumor cells and show the

Identifiers

PMID33282485
PMCPMC7687927
OpenAlexW3088342403

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.