ArticleJournal of thoracic disease2020
Acute Stanford type B aortic dissection-who benefits from genetic testing?
Article in Journal of thoracic disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Interdisciplinary vascular genetics evaluations in routine clinical care: insights from a five-year single-center experience.Langenbeck's archives of surgery · 2026Article
- Clinical follow-up and predictors of re-intervention following thoracic endovascular aortic repair for Stanford type B aortic dissection.American journal of translational research · 2026Article
- Genetic variants in patients with multiple arterial aneurysms.Langenbeck's archives of surgery · 2024Article
- Central nervous injury risk factors after endovascular repair of a thoracic aortic aneurysm with type B aortic dissection.World journal of clinical cases · 2024Article
- Association of gene polymorphisms in FBN1 and TGF-β signaling with the susceptibility and prognostic outcomes of Stanford type B aortic dissection.BMC medical genomics · 2022Article
- Genetic Variation inJournal of cardiovascular development and disease · 2022Article
- Association of genetic variants inFrontiers in genetics · 2022Article
- Applying multi-omics techniques to the discovery of biomarkers for acute aortic dissection.Frontiers in cardiovascular medicine · 2022Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStanford type B aortic dissection is a rare, life-threatening complex phenotype associated with several modifiable and genetic risk factors. In the current study of a hospital-based, consecutive series of aortic dissection patients we propose a selection based on age and family history of aortic disease for genetic testing and detection of causative gene variants.
methodsIn this single center cohort study from 2013 to 2018 patients with acute Stanford type B aortic dissections were consecutively treated and analyzed by next generation sequencing based on selection criteria (age of disease onset ≤45 years and/or positive familial history for aortic disease) to detect genome-wide pathogenic variants in protein-coding sequences and to identify large copy number variants (CNV). Variants in a predefined panel of 30 genes associated with the familial thoracic aortic aneurysm and dissection (TAAD) syndrome were evaluated.
resultsFrom 105 patients nine matched selection criteria for genetic testing. Next-generation sequencing analysis revealed causal variants in
conclusionsSelection of patients on the basis of young age and familial inheritance of aortic disease favors the identification of disease-causing genetic variants in a clinical cohort of patients with Stanford type B aortic dissection.
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