Evidence map›Paper›PMID 33282293›Full record

ArticleClinical & translational immunology2020

Involvement of activated cytotoxic T lymphocytes and natural killer cells in Henoch-Schönlein purpura nephritis.

Takashi Imai, Kei Nishiyama, Kenji Ueki, Tamami Tanaka, Yoshitsugu Kaku, Toshiro Hara, Shouichi Ohga

Open access · goldAbstract read
In one paragraph

Article in Clinical & translational immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Modern biomarkers in IgA vasculitis with nephritis in children.Central-European journal of immunology · 2025
    Review
  5. Article
  6. Article
  7. [Research advances in the etiology and pathogenesis of immunoglobulin A vasculitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023
    Review
  8. Article
  9. Immunosenescence: an unexplored role in glomerulonephritis.Clinical & translational immunology · 2022
    Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Takashi ImaiDepartment of Pediatrics Graduate School of Medical Sciences Kyushu University Fukuoka Japan.ORCID https://orcid.org/0000-0002-8027-4647
Kei NishiyamaDepartment of Pediatrics Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Kenji UekiDepartment of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Tamami TanakaDepartment of Pediatrics Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Yoshitsugu KakuDepartment of Pediatric Nephrology Fukuoka Children's Hospital Fukuoka Japan.ORCID https://orcid.org/0000-0002-9761-066X
Toshiro HaraKawasaki Disease Center Fukuoka Children's Hospital Fukuoka Japan.
Shouichi OhgaDepartment of Pediatrics Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Kyushu University · JPFukuoka Children's Hospital and Medical Center for Infectious Diseases · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesImmunoglobulin A vasculitis/Henoch-Schönlein purpura (IgAV/HSP) is a major cause of vasculitis in children. It is often accompanied by nephritis (HSPN) and could progress to chronic kidney disease. Galactose-deficient IgA

methodsWe compared gene expressions of peripheral blood mononuclear cells (PBMCs) among healthy controls (

results

conclusionActivated CTLs and NK cells play roles in the development of nephritis in IgAV/HSP patients and can be used as novel biomarkers for HSPN.

Indexed as

biomarkerCX3CL1/fractalkineHenoch–Schönlein purpura nephritisHLA‐DRIgA vasculitis

Identifiers

PMID33282293
PMCPMC7684975
OpenAlexW3109260178

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.