Evidence map›Paper›PMID 33282286›Full record

ArticleMolecular and clinical oncology2021

A population-based study of outcomes in patients with surgically resected non-small cell lung cancer with anaplastic lymphoma kinase-rearranged mutations: A matched-pair study.

Masaharu Inagaki, Hideo Ichimura, Shingo Usui, Kesato Iguchi, Osamu Ishibashi, Ryota Nakamura, Yoshihisa Inage, Hisashi Suzuki, Moriyuki Kiyoshima, Koichi Kamiyama and 8 more

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Article in Molecular and clinical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 76% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 1 country.

Masaharu InagakiDepartment of Thoracic Surgery, Tsuchiura Kyodo General Hospital, Tsuchiura, Ibaraki 3000028, Japan.
Hideo IchimuraDivisions of Thoracic Surgery, Hitachi General Hospital, Hitachi, Ibaraki 3170077, Japan.
Shingo UsuiDivision of Thoracic Surgery, Ibarakihigashi Hospital, Tokai-mura, Ibaraki 3191113, Japan.
Kesato IguchiDivision of Respiratory Medicine and Thoracic Surgery, Mito Medical Center, University of Tsukuba-Mito Kyodo General Hospital, Mito, Ibaraki 3100015, Japan.
Osamu IshibashiDivision of Respiratory Medicine and Thoracic Surgery, Mito Medical Center, University of Tsukuba-Mito Kyodo General Hospital, Mito, Ibaraki 3100015, Japan.
Ryota NakamuraDivision of Thoracic Surgery, Mito Medical Center, Mito, Ibaraki 3113193, Japan.
Yoshihisa InageDivision of Thoracic Surgery, Mito Medical Center, Mito, Ibaraki 3113193, Japan.
Hisashi SuzukiRespiratory Center, Ibaraki Prefectural Central Hospital, Kasama, Ibaraki 3091703, Japan.
Moriyuki KiyoshimaRespiratory Center, Ibaraki Prefectural Central Hospital, Kasama, Ibaraki 3091703, Japan.
Koichi KamiyamaDivision of Thoracic Surgery, Tsukuba Memorial Hospital, Tsukuba, Ibaraki 3002622, Japan.
Masaki KimuraDivision of Thoracic Surgery, Tsukuba Memorial Hospital, Tsukuba, Ibaraki 3002622, Japan.
Susumu YoshidaDivision of Thoracic Surgery, Ibaraki Seinan Medical Center Hospital, Sakai-machi, Ibaraki 3060433, Japan.
Mitsuaki SakaiDivision of Thoracic Surgery, Tsukuba Medical Center Hospital, Tsukuba, Ibaraki 3058558, Japan.
Naohiro KobayashiFaculty of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 3058575, Japan.
Kinya FurukawaDivision of Thoracic Surgery, Tokyo Medical University, Ibaraki Medical Center, Ami-machi, Ibaraki 3113193, Japan.
Hiroaki SatohDivision of Respiratory Medicine and Thoracic Surgery, Mito Medical Center, University of Tsukuba-Mito Kyodo General Hospital, Mito, Ibaraki 3100015, Japan.
Nobuyuki HizawaFaculty of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 3058575, Japan.
Yukio SatoFaculty of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 3058575, Japan.
National Hospital Organization Mito Medical Center · JPUniversity of Tsukuba · JPIbaraki Prefectural Central Hospital · JPTsukuba Memorial Hospital · JPHitachi General Hospital · JPIbarakihigashi National Hospital · JPTokyo Medical University Ibaraki Medical Center · JPTsuchiura Kyodo General Hospital · JPTsukuba Medical Center Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aimed to evaluate clinical outcomes in patients with surgically resected non-small cell lung cancer (NSCLC) with anaplastic lymphoma kinase (ALK)-rearranged mutations. A matched-pair analysis in completely resected ALK-rearranged NSLC patients and those with neither ALK nor epidermal growth factor receptor (EGFR) mutations diagnosed at 11 institutes was performed between April 2008 and March 2019. A total of 51 patients with surgically resected ALK-rearranged NSCLC were included. Women constituted 68.6%, and smokers 29.4%. The median age was 65 years. In matched-pair analysis, disease-free survival and overall survival did not differ between patients with ALK-rearranged mutations and those without mutations. Post-recurrence survival in patients with ALK mutations was longer than that of patients with neither ALK nor epidermal growth factor receptor mutations. ALK genetic testing should be performed, even in elderly patients with NSCLC. Favorable prognosis might be expected after appropriate treatment for patients with recurrent ALK-mutated disease.

Indexed as

anaplastic lymphoma kinase fusion gene mutationclinical practicenon-small cell lung cancerrecurrencesurgery

Identifiers

PMID33282286
PMCPMC7709561
OpenAlexW3102506608

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.