ArticleTherapeutic advances in psychopharmacology2020
Early labor force exits in patients with treatment-resistant depression: an assessment of work years lost in a Danish nationwide register-based cohort study.
Article in Therapeutic advances in psychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Barriers and facilitators to implementing workplace interventions to promote mental health: qualitative evidence synthesis.Systematic reviews · 2024Pooled it
- Article
- One Health Approach to Nutritional Status and Well-Being in Food Supply Chain Workers: A Study Protocol.International journal of environmental research and public health · 2026Article
- Healthcare utilization, costs, and productivity losses in treatment-resistant depression in Finland - a matched cohort study.BMC psychiatry · 2022Article
- Treatment-resistant depression and labor market affiliation in the Danish welfare society: a register-based study.Social psychiatry and psychiatric epidemiology · 2022Article
- Healthcare resource utilization in patients with treatment-resistant depression-A Danish national registry study.PloS one · 2022Article
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Authors and funding
8 authors.
Funding
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Abstract
backgroundDepression is one of the leading causes of premature workforce exit in many Western countries, but little is known about the extent to which treatment-resistance reduces number of work-years. We compared the risk of premature workforce exit among patients with treatment-resistant depression (TRD) relative to non-TRD patients and estimated work years lost (WYL) before scheduled retirement age.
methodsThe study population, identified in the Danish National Prescription Registry, included all individuals born and living in Denmark who redeemed their first antidepressant (AD) prescription for depression at age 18-60 years between 2005 and 2012. TRD was defined as failure to respond to at least two different treatment trials. Premature workforce exit was measured using disability pension records. We used Cox regression to estimate the hazard ratio (HR) for premature workforce exit in TRD relative to non-TRD patients, adjusting for calendar year, psychiatric and somatic comorbidity, and educational level. Differences in WYL in patients with TRD and all depression patients were estimated through a competing risks model.
resultsOut of the total sample of patients with depression (
conclusionPatients with TRD constitute a small group within depression patients, but contribute disproportionally to societal costs due to premature workforce exit at a young age.
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