ArticleDental research journal
The comparison of the salivary concentration of interleukin-17 and interleukin-18 in patients with chronic periodontitis and healthy individuals.
Article in Dental research journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- A systematic review of the implications of lipocalin-2 expression in periodontal disease.Evidence-based dentistry · 2025Pooled it
- Increased of IL-18 levels are associated with periodontitis: a systematic review and meta-analysis.BMC oral health · 2024Pooled it
- Salivary interleukin-17A and interleukin-18 levels in patients with celiac disease and periodontitis.PeerJ · 2024Article
- Article
- The diagnostic utility of IL-10, IL-17, and PCT in patients with sepsis infection.Frontiers in public health · 2022Article
- Comparative evaluation of serum and gingival crevicular fluid levels of interleukin 21 in periodontally diseased and healthy patients.Journal of circulating biomarkersArticle
- Efficacy of Xanthan-Based Chlorhexidine Gel on the Levels of Interleukin-1β in Chronic Periodontitis: An Interventional Study.Journal of International Society of Preventive & Community DentistryArticle
- Flow cytometry-based evaluation of CD4/CD25 and IL-17 expression in sepsis of cancer surgical patients.International journal of immunopathology and pharmacologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRegarding the prevalence and importance of periodontal disease and the potential of salivary biomarkers for the early diagnosis of these diseases, this study was conducted to compare salivary concentrations of Interleukin-17 (IL-17) and Interleukin-18 (IL-18) in patients with chronic periodontitis and healthy individuals. MATERIALS AND
methodsThe present research was a descriptive-analytical and also a cross-sectional study. Unstimulated saliva with full-mouth clinical periodontal recordings were obtained from 20 healthy individuals and 20 individuals with chronic periodontitis. The concentrations of salivary IL-17 and IL-18 were determined using the enzyme-linked immunosorbent assays. The nonparametric Mann-Whitney U-test was used for statistical analysis of the findings. Alpha level was set at 0.05.
resultsThe mean salivary concentration of IL-18 in patients with chronic periodontitis was 143.10 pg/mL, which was higher than the same concentration in healthy controls (78.33 pg/mL), (
conclusionWithin the limitations of the present study, it may be suggested that an elevated salivary IL-18 level in chronic periodontitis patients has the potential to be a biomarker for periodontal tissue destruction.
Indexed as
Identifiers
33282154PMC7688042W3049177770What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.