Evidence map›Paper›PMID 33282109›Full record

ReviewThe Journal of clinical and aesthetic dermatology2020

THE SKIN MICROBIOTA AND ITCH: Is There a Link?

Hei Sung Kim, Gil Yosipovitch

Open access · greenAbstract readReview
PubMed Full text at PMC
In one paragraph

Review in The Journal of clinical and aesthetic dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hei Sung KimDr. Kim is with the Department of Dermatology and Cutaneous Surgery at Miami Itch Center, Miller School of Medicine at University of Miami in Miami, Florida, the Department of Dermatology at Incheon St. Mary's Hospital, The Catholic University of Korea in Seoul, Korea, and the Department of Biomedicine and Health Sciences, at The Catholic University of Korea in Seoul, Korea.
Gil YosipovitchDr. Kim is with the Department of Dermatology and Cutaneous Surgery at Miami Itch Center, Miller School of Medicine at University of Miami in Miami, Florida, the Department of Dermatology at Incheon St. Mary's Hospital, The Catholic University of Korea in Seoul, Korea, and the Department of Biomedicine and Health Sciences, at The Catholic University of Korea in Seoul, Korea.
St. Paul's Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Itch is an unpleasant sensation that emanates primarily from the skin. The chemical mediators that drive neuronal activity originate from a complex interaction between keratinocytes, inflammatory cells, nerve endings, and the skin microbiota, relaying itch signals to the brain. Stress also exacerbates itch via the skin-brain axis. Recently, the microbiota has surfaced as a major player to regulate this axis, notably during stress settings aroused by actual or perceived homeostatic challenge. The routes of communication between the microbiota and brain are slowly being unraveled and involve neurochemicals (i.e., acetylcholine, histamine, catecholamines, and corticotropin) that originate from the microbiota itself. By focusing on itch biology and by referring to the more established field of pain research, this review examines the possible means by which the skin microbiota contributes to itch.

Indexed as

Itchmicrobiota-skin-brain axisskin microbiotastress

Identifiers

PMID33282109
PMCPMC7710288
OpenAlexW3200990886

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.