Evidence map›Paper›PMID 33281829›Full record

ArticleFrontiers in immunology2020

Fusion of Bacterial Flagellin to a Dendritic Cell-Targeting αCD40 Antibody Construct Coupled With Viral or Leukemia-Specific Antigens Enhances Dendritic Cell Maturation and Activates Peptide-Responsive T Cells.

Saskia Schmitt, Siret Tahk, Alina Lohner, Gerulf Hänel, Andreas Maiser, Martina Hauke, Lubna Patel, Maurine Rothe, Christine Josenhans, Heinrich Leonhardt and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Saskia SchmittGene Center and Department of Biochemistry, Ludwig Maximilians University Munich, Munich, Germany.
Siret TahkGene Center and Department of Biochemistry, Ludwig Maximilians University Munich, Munich, Germany.
Alina LohnerDepartment of Medicine III, University Hospital, Ludwig Maximilians University Munich, Munich, Germany.
Gerulf HänelDepartment of Medicine III, University Hospital, Ludwig Maximilians University Munich, Munich, Germany.
Andreas MaiserDepartment of Biology II, Center for Integrated Protein Science, Ludwig Maximilians University Munich, Munich, Germany.
Martina HaukeMax von Pettenkofer Institute, Ludwig Maximilians University Munich, Munich, Germany.
Lubna PatelMax von Pettenkofer Institute, Ludwig Maximilians University Munich, Munich, Germany.
Maurine RotheDepartment of Medicine III, University Hospital, Ludwig Maximilians University Munich, Munich, Germany.
Christine JosenhansMax von Pettenkofer Institute, Ludwig Maximilians University Munich, Munich, Germany.
Heinrich LeonhardtDepartment of Biology II, Center for Integrated Protein Science, Ludwig Maximilians University Munich, Munich, Germany.
Marieke GriffioenDepartment of Hematology, Leiden University Medical Center, Leiden, Netherlands.
Katrin DeiserDepartment of Medicine III, University Hospital, Ludwig Maximilians University Munich, Munich, Germany.
Nadja C FennGene Center and Department of Biochemistry, Ludwig Maximilians University Munich, Munich, Germany.
Karl-Peter HopfnerGene Center and Department of Biochemistry, Ludwig Maximilians University Munich, Munich, Germany.
Marion SubkleweDepartment of Medicine III, University Hospital, Ludwig Maximilians University Munich, Munich, Germany.
Ludwig-Maximilians-Universität München · DECenter for Integrated Protein Science Munich · DEGerman Center for Infection Research · DELeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional dendritic cell (DC) vaccine strategies, in which DCs are loaded with antigens

Indexed as

Lymphocyte ActivationAntibodiesCancer VaccinesCD40 AntigensCell CommunicationCell Line, TumorCell ProliferationCoculture TechniquesDendritic CellsEpitopesFilaggrin ProteinsFlagellinHEK293 CellsHumansNuclear ProteinsNucleophosminAntibodiesCancer VaccinesCD40 Antigenscytomegalovirus matrix protein 65kDaEpitopesFilaggrin ProteinsFlagellinFLG protein, humanNPM1 protein, humanNpm1 protein, mouseNuclear ProteinsNucleophosminRecombinant Fusion ProteinsTLR5 protein, humanToll-Like Receptor 5Viral Matrix Proteinsacute myeloid leukemiaantibodydendritic cellflagellinneoantigenvaccine

Identifiers

PMID33281829
PMCPMC7689061
OpenAlexW3105046991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.