Evidence map›Paper›PMID 33281808›Full record

ReviewFrontiers in immunology2020

Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease.

Jeffery A Goldstein, Kelly Gallagher, Celeste Beck, Rajesh Kumar, Alison D Gernand

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jeffery A GoldsteinDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Kelly GallagherDepartment of Nutritional Sciences, College of Health and Human Development, Penn State University, University Park, PA, United States.
Celeste BeckDepartment of Nutritional Sciences, College of Health and Human Development, Penn State University, University Park, PA, United States.
Rajesh KumarSection of Allergy and Immunology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital and Northwestern University, Chicago, IL, United States.
Alison D GernandDepartment of Nutritional Sciences, College of Health and Human Development, Penn State University, University Park, PA, United States.

Funding

Developing a virtual placenta biobankK08EB030120 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOLDSTEIN, JEFFERY A · 2020 to 2023
$575k
NIBIB NIH HHS K08 EB030120
6 · The paper itself

Abstract

Events in fetal life impact long-term health outcomes. The placenta is the first organ to form and is the site of juxtaposition between the maternal and fetal circulations. Most diseases of pregnancy are caused by, impact, or are reflected in the placenta. The purpose of this review is to describe the main inflammatory processes in the placenta, discuss their immunology, and relate their short- and long-term disease associations. Acute placental inflammation (API), including maternal and fetal inflammatory responses corresponds to the clinical diagnosis of chorioamnionitis and is associated with respiratory and neurodevelopmental diseases. The chronic placental inflammatory pathologies (CPI), include chronic villitis of unknown etiology, chronic deciduitis, chronic chorionitis, eosinophilic T-cell vasculitis, and chronic histiocytic intervillositis. These diseases are less-well studied, but have complex immunology and show mechanistic impacts on the fetal immune system. Overall, much work remains to be done in describing the long-term impacts of placental inflammation on offspring health.

Indexed as

FemaleFetusHumansInflammationPlacentaPlacenta DiseasesPregnancyasthmachorioamnionitischronic villitisDOHaDmaternal-fetal inflammationneurodevelopmental outcomesplacenta

Identifiers

PMID33281808
PMCPMC7691234

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.