Evidence map›Paper›PMID 33281746›Full record

ArticleFrontiers in endocrinology2020

Somatic Deletion in Exon 10 of Aryl Hydrocarbon Receptor Gene in Human GH-Secreting Pituitary Tumors.

Agnese Re, Francesco Ferraù, Concetta Cafiero, Federica Spagnolo, Valeria Barresi, Daniela Petronilla Romeo, Marta Ragonese, Claudio Grassi, Alfredo Pontecorvi, Antonella Farsetti and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Agnese ReInstitute for Systems Analysis and Computer Science "A. Ruberti" (IASI), National Research Council (CNR), Rome, Italy.
Francesco FerraùDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy.
Concetta CafieroMedical Oncology, S.G. Moscati Hospital, Taranto, Italy.
Federica SpagnoloEndocrine Unit, University Hospital G. Martino, Messina, Italy.
Valeria BarresiDepartment of Diagnostic and Public Health, Section of Pathology, University of Verona, Verona, Italy.
Daniela Petronilla RomeoDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy.
Marta RagoneseDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy.
Claudio GrassiDipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy.
Alfredo PontecorviFondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Antonella FarsettiInstitute for Systems Analysis and Computer Science "A. Ruberti" (IASI), National Research Council (CNR), Rome, Italy.
Salvatore CannavòDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy.
University of Messina · ITAgostino Gemelli University Polyclinic · ITIstituto di Analisi dei Sistemi ed Informatica Antonio Ruberti · ITAzienda Ospedaliera S.Giuseppe Moscati · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective/Purpose: The aryl hydrocarbon receptor (AHR) pathway plays a critical role in the biology of Growth Hormone (GH)-secreting pituitary tumor (somatotropinoma). Germline rs2066853 Methods: A cohort of 13 patients aged 20-76 years with biochemical, clinical and histological diagnosis of somatotropinoma was studied. DNA and RNA from pituitary tumor histological samples have been extracted and analyzed by PCR and direct sequencing for Results: A degenerated letter codes in the region corresponding to Conclusion: This is the first demonstration of a recurrent somatic deletion in the exon 10 of the

Indexed as

ExonsAdenomaAdultAgedBasic Helix-Loop-Helix ProteinsBiomarkers, TumorCohort StudiesFemaleFollow-Up StudiesGene DeletionGrowth Hormone-Secreting Pituitary AdenomaHumansLoss of HeterozygosityMaleMiddle AgedPrognosisAHR protein, humanBasic Helix-Loop-Helix ProteinsBiomarkers, TumorReceptors, Aryl Hydrocarbonacromegalyaryl hydrocarbon receptorpituitary adenomasequencing analysissomatic deletion

Identifiers

PMID33281746
PMCPMC7689685
OpenAlexW3103079246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.