Evidence map›Paper›PMID 33281589›Full record

ReviewFrontiers in human neuroscience2020

Update on the Use of Transcranial Electrical Brain Stimulation to Manage Acute and Chronic COVID-19 Symptoms.

Giuseppina Pilloni, Marom Bikson, Bashar W Badran, Mark S George, Steven A Kautz, Alexandre Hideki Okano, Abrahão Fontes Baptista, Leigh E Charvet

Registry-linked trialAbstract readReview
In one paragraph

Review in Frontiers in human neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05886647 (Non-invasive Neurostimulation and Rehabilitation in the Treatment of Patients With Respiratory Disorders), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05886647 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Non-invasive Neurostimulation and Rehabilitation in the Treatment of Patients With Respiratory Disorders: Randomized Controlled Clinical Trial

TypeinterventionalSponsorSuellen AndradeRan2023 to 2024Enrolled30ConditionsLung DiseasesArmsActive non-invasive stimulation and inspiratory muscle training, Sham compatorator and inspiratory muscle training
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review.International journal of environmental research and public health · 2023
    Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Global Trends and Research Hotspots in Long COVID: A Bibliometric Analysis.International journal of environmental research and public health · 2022
    Article
  11. Review
  12. Review
  13. Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giuseppina PilloniDepartment of Neurology, NYU Langone Health, New York, NY, United States.
Marom BiksonDepartment of Biomedical Engineering, The City College of New York, New York, NY, United States.
Bashar W BadranDepartment of Psychiatry, Medical University of South Carolina, Charleston, SC, United States.
Mark S GeorgeDepartment of Psychiatry, Medical University of South Carolina, Charleston, SC, United States.
Steven A KautzRalph H Johnson Veterans Affairs Medical Center, Charleston, SC, United States.
Alexandre Hideki OkanoCenter for Mathematics, Computation and Cognition, Universidade Federal do ABC, São Bernardo do Campo, Brazil.
Abrahão Fontes BaptistaCenter for Mathematics, Computation and Cognition, Universidade Federal do ABC, São Bernardo do Campo, Brazil.
Leigh E CharvetDepartment of Neurology, NYU Langone Health, New York, NY, United States.

Funding

Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Gregory E Hicks · 2013 to 2026
$60.5M
Treating Depression and Enhancing Locomotor Recovery Post-strokeP20GM109040 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KAUTZ, STEVEN A. · 2014 to 2024
$23.5M
Techniques DevelopmentP2CHD086844 · NICHD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GEORGE, MARK S · 2015 to 2024
$12.7M
Temporal dynamics of neurophysiological patterns as treatment targets in SzR01MH109289 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI JAVITT, DANIEL C. · 2016 to 2020
$3.7M
A tool-box to control and enhance tDCS spatial precisionR01MH111896 · NIMH · CITY COLLEGE OF NEW YORK · PI BIKSON, MAROM · 2016 to 2019
$2.2M
Open-source computational modeling of Spinal Cord Stimulation (SCS) to enhance dissemination of 1R01NS112996R01NS112996 · NINDS · CITY COLLEGE OF NEW YORK · PI BIKSON, MAROM · 2020 to 2024
$2.0M
The coupled vascular hypothesis for transcranial direct current stimulation (tDCS)R01NS101362 · NINDS · CITY COLLEGE OF NEW YORK · PI BIKSON, MAROM · 2017 to 2021
$1.7M
Effects of direct-current stimulation on synaptic plasticityR01NS095123 · NINDS · CITY COLLEGE OF NEW YORK · PI PARRA, LUCAS C · 2016 to 2020
$1.7M
NICHD NIH HHS P2C HD086844NIGMS NIH HHS P20 GM109040NIGMS NIH HHS U54 GM104941NIMH NIH HHS R01 MH109289NIMH NIH HHS R01 MH111896NINDS NIH HHS R01 NS095123NINDS NIH HHS R01 NS101362NINDS NIH HHS R01 NS112996RRD VA IK6 RX003075
6 · The paper itself

Abstract

The coronavirus disease 19 (COVID-19) pandemic has resulted in the urgent need to develop and deploy treatment approaches that can minimize mortality and morbidity. As infection, resulting illness, and the often prolonged recovery period continue to be characterized, therapeutic roles for transcranial electrical stimulation (tES) have emerged as promising non-pharmacological interventions. tES techniques have established therapeutic potential for managing a range of conditions relevant to COVID-19 illness and recovery, and may further be relevant for the general management of increased mental health problems during this time. Furthermore, these tES techniques can be inexpensive, portable, and allow for trained self-administration. Here, we summarize the rationale for using tES techniques, specifically transcranial Direct Current Stimulation (tDCS), across the COVID-19 clinical course, and index ongoing efforts to evaluate the inclusion of tES optimal clinical care.

Indexed as

COVID-19mental healthNEUROCOVIDneuropsychiatrictDCSTESTMS

Identifiers

PMID33281589
PMCPMC7689057

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.