Evidence map›Paper›PMID 33281581›Full record

ArticleFrontiers in human neuroscience2020

Researcher Perspectives on Ethical Considerations in Adaptive Deep Brain Stimulation Trials.

Katrina A Muñoz, Kristin Kostick, Clarissa Sanchez, Lavina Kalwani, Laura Torgerson, Rebecca Hsu, Demetrio Sierra-Mercado, Jill O Robinson, Simon Outram, Barbara A Koenig and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in human neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Neurostimulation treatments for epilepsy: Deep brain stimulation, responsive neurostimulation and vagus nerve stimulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
  10. Post-trial access to implantable neural devices: an exploratory international survey.BMJ surgery, interventions, & health technologies · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. A Call for Behavioral Science in Embedded Bioethics.Perspectives in biology and medicine · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Trust in Neuroethics.AJOB neuroscience
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Katrina A MuñozCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, United States.
Kristin KostickCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, United States.
Clarissa SanchezCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, United States.
Lavina KalwaniDepartment of Neuroscience, Rice University, Houston, TX, United States.
Laura TorgersonCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, United States.
Rebecca HsuEvans School of Public Policy & Governance, University of Washington, Seattle, WA, United States.
Demetrio Sierra-MercadoCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, United States.
Jill O RobinsonCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, United States.
Simon OutramProgram in Bioethics, University of California, San Francisco, San Francisco, CA, United States.
Barbara A KoenigProgram in Bioethics, University of California, San Francisco, San Francisco, CA, United States.
Stacey PereiraCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, United States.
Amy McGuireCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, United States.
Peter ZukCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, United States.
Gabriel Lázaro-MuñozCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, United States.
Baylor College of Medicine · USUniversity of California, San Francisco · USRice University · USUniversity of Puerto Rico System · PRUniversity of Washington · US

Funding

Neuroethics of aDBS Systems Targeting Neuropsychiatric and Movement DisordersR01MH114854 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI GOODMAN, WAYNE K, LAZARO-MUNOZ, GABRIEL · 2017 to 2020
$2.1M
NIMH NIH HHS R01 MH114854
6 · The paper itself

Abstract

Interest and investment in closed-loop or adaptive deep brain stimulation (aDBS) systems have quickly expanded due to this neurotechnology's potential to more safely and effectively treat refractory movement and psychiatric disorders compared to conventional DBS. A large neuroethics literature outlines potential ethical concerns about conventional DBS and aDBS systems. Few studies, however, have examined stakeholder perspectives about ethical issues in aDBS research and other next-generation DBS devices. To help fill this gap, we conducted semi-structured interviews with researchers involved in aDBS trials (

Indexed as

bioethicsclosed-loopdeep brain stimulationELSIethicsinterviewsneuroethicsneuromodulation

Identifiers

PMID33281581
PMCPMC7689343
OpenAlexW3104321843

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.