ArticleJournal of molecular liquids2021
Modeling and simulations of CoViD-19 molecular mechanism induced by cytokines storm during SARS-CoV2 infection.
Article in Journal of molecular liquids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Modelling of the Innate and Adaptive Immune Response to SARS Viral Infection, Cytokine Storm and Vaccination.Vaccines · 2023Article
- Alloferon and Zanamivir Show Effective Antiviral Activity against Influenza A Virus (H1N1) Infection In Vitro and In Vivo.International journal of molecular sciences · 2022Article
- Modeling the crossover behavior of the bacterial infection with the COVID-19 epidemics.Results in physics · 2022Article
- A security-aware service function chain deployment method for load balance and delay optimization.Scientific reports · 2022Article
- COVID-19 Variants and Transfer Learning for the Emerging Stringency Indices.Neural processing letters · 2022Article
- Immune Signature of COVID-19: In-Depth Reasons and Consequences of the Cytokine Storm.International journal of molecular sciences · 2022Review
- Forecasting of the efficiency of monoclonal therapy in the treatment of CoViD-19 induced by the Omicron variant of SARS-CoV2.Results in physics · 2022Article
- Immunoediting in SARS-CoV-2: Mutual relationship between the virus and the host.International immunopharmacology · 2022Review
- An efficient density peak cluster algorithm for improving policy evaluation performance.Scientific reports · 2022Article
- The impact of vaccination on the spread of COVID-19: Studying by a mathematical model.Physica A · 2022Article
- Piecewise differentiation of the fractional order CAR-T cells-SARS-2 virus model.Results in physics · 2022Article
- Furin and the adaptive mutation of SARS-COV2: a computational framework.Modeling earth systems and environment · 2022Article
- Computational model to explore the endocrine response to trastuzumab action in HER-2/neu positive breast cancer.Saudi journal of biological sciences · 2022Article
- Improvement on PDP Evaluation Performance Based on Neural Networks and SGDK-means Algorithm.Soft computing · 2022Article
- Preparing for the next pandemic: Simulation-based deep reinforcement learning to discover and test multimodal control of systemic inflammation using repurposed immunomodulatory agents.Frontiers in immunology · 2022Article
- Self organizing maps for the parametric analysis of COVID-19 SEIRS delayed model.Chaos, solitons, and fractals · 2021Article
- Forecasting the impact of environmental stresses on the frequent waves of COVID19.Nonlinear dynamics · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is highly desired to explore the interventions of COVID-19 for early treatment strategies. Such interventions are still under consideration. A model is benchmarked research and comprises target cells, virus infected cells, immune cells, pro-inflammatory cytokines, and, anti-inflammatory cytokine. The interaction of the drug with the inflammatory sub-system is analyzed with the aid of kinetic modeling. The impact of drug therapy on the immune cells is modelled and the computational framework is verified with the aid of numerical simulations. The work includes a significant hypothesis that quantifies the complex dynamics of the infection, by relating it to the effect of the inflammatory syndrome generated by IL-6. In this paper we use the cancer immunoediting process: a dynamic process initiated by cancer cells in response to immune surveillance of the immune system that it can be conceptualized by an alternating movement that balances immune protection with immune evasion. The mechanisms of resistance to immunotherapy seem to broadly overlap with those used by cancers as they undergo immunoediting to evade detection by the immune system. In this process the immune system can both constrain and promote tumour development, which proceeds through three phases termed: (i) Elimination, (ii) Equilibrium, and, (iii) Escape [1]. We can also apply these concepts to viral infection, which, although it is not exactly "immunoediting", has many points in common and helps to understand how it expands into an "untreated" host and can help in understanding the SARS-CoV2 virus infection and treatment model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.