Evidence map›Paper›PMID 33281034›Full record

ReviewTrends in cell biology2021

Cell Migration Guided by Cell-Cell Contacts in Innate Immunity.

Veronika Miskolci, Lucas C Klemm, Anna Huttenlocher

Abstract readReview
In one paragraph

Review in Trends in cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Chemical and Mechanical Regulation of Leukocyte Migration.Cold Spring Harbor perspectives in biology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Integration of immune cells in organs-on-chips: a tutorial.Frontiers in bioengineering and biotechnology · 2023
    Review
  9. Novel Regioisomeric Analogues of Naphthyl-International journal of molecular sciences · 2022
    Article
  10. Epithelial sodium channels in macrophage migration and polarization: role of proinflammatory cytokines TNFα and IFNγ.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
  11. Article
  12. [Design, simulation and application of multichannel microfluidic chip for cell migration].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2022
    Article
  13. Lipoxin ABrain sciences · 2022
    Article
  14. Review
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Veronika MiskolciDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA.
Lucas C KlemmDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA; Molecular and Cellular Pharmacology Graduate Training Program, University of Wisconsin-Madison, Madison, WI, USA.
Anna HuttenlocherDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA; Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: huttenlocher@wisc.edu.

Funding

Cell migration and wound repairR35GM118027 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher · 2016 to 2026
$7.5M
Training Program In Molecular AND Cellular PharmacologyT32GM008688 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI AUDHYA, ANJON · 1998 to 2020
$6.0M
NIGMS NIH HHS R35 GM118027NIGMS NIH HHS T32 GM008688
6 · The paper itself

Abstract

The directed migration of leukocytes to sites of damage or infection is necessary for a productive immune response. There is substantial evidence supporting a key role for chemoattractants in directed migration, however, less is known about how cell-cell contacts affect the migratory behavior of leukocytes in innate immunity. Here, we explore how cell-cell contacts can affect the directed migration of innate immune cells, including their role in attracting, repelling, or stopping cell motility. Further investigation of cell contact dynamics as guidance cues may yield new insights into the regulation of innate immunity.

Indexed as

Cell CommunicationImmunity, InnateAnimalsCell MovementHumansNeutrophilsSignal Transductioncell–cell contactmacrophagesmigrationneutrophils

Identifiers

PMID33281034
PMCPMC9057246

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.