Evidence map›Paper›PMID 33280509›Full record

ArticleRNA biology2021

Distinct roles of nucleosome sliding and histone modifications in controlling the fidelity of transcription initiation.

Huiming Zhang, Zhaolian Lu, Yu Zhan, Judith Rodriguez, Chen Lu, Yong Xue, Zhenguo Lin

Open access · bronzeAbstract read
In one paragraph

Article in RNA biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Huiming ZhangJiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, China.
Zhaolian LuDepartment of Biology, Saint Louis University, St. Louis, Missouri, USA.
Yu ZhanDepartment of Biology, Saint Louis University, St. Louis, Missouri, USA.
Judith RodriguezProgram of Bioinformatics and Computational Biology, Saint Louis University, St. Louis, Missouri, USA.
Chen LuJiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, China.
Yong XueJiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, China.ORCID 0000-0002-7229-7232
Zhenguo LinDepartment of Biology, Saint Louis University, St. Louis, Missouri, USA.
Saint Louis University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulation of gene expression starts from the transcription initiation. Regulated transcription initiation is critical for generating correct transcripts with proper abundance. The impact of epigenetic control, such as histone modifications and chromatin remodelling, on gene regulation has been extensively investigated, but their specific role in regulating transcription initiation is far from well understood. Here we aimed to better understand the roles of genes involved in histone H3 methylations and chromatin remodelling on the regulation of transcription initiation at a genome-scale using the budding yeast as a study system. We obtained and compared maps of transcription start site (TSS) at single-nucleotide resolution by nAnT-iCAGE for a strain with depletion of MINC (Mot1-Ino80C-Nc2) by Mot1p and Ino80p anchor-away (

Indexed as

Chromatin Assembly and DisassemblyGene Expression RegulationTranscription Initiation SiteAdenosine TriphosphatasesHistone CodeHistone-Lysine N-MethyltransferaseHistonesMethyltransferasesNuclear ProteinsNucleosomesPromoter Regions, GeneticSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTATA-Binding Protein Associated FactorsTATA-Box Binding ProteinTranscription, GeneticAdenosine TriphosphatasesDot1 protein, S cerevisiaeHistone-Lysine N-MethyltransferaseHistonesMethyltransferasesMOT1 protein, S cerevisiaeNuclear ProteinsNucleosomesSaccharomyces cerevisiae ProteinsSET1 protein, S cerevisiaeSet2 protein, S cerevisiaeTATA-Binding Protein Associated FactorsTATA-Box Binding ProteinCAGE-Seqhistone methylationMINCTATATranscription initiation

Identifiers

PMID33280509
PMCPMC8583300
OpenAlexW3111501487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.