Evidence map›Paper›PMID 33280503›Full record

SynthesisJournal of the American Heart Association2020

Exercise Reduces Ambulatory Blood Pressure in Patients With Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Gonzalo Saco-Ledo, Pedro L Valenzuela, Gema Ruiz-Hurtado, Luis M Ruilope, Alejandro Lucia

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06612099 (Comparison of the Effects of Aerobic Exercise Training and Mat Pilates Exercise on Blood Pressure, Functional Capacity and Quality of Life in Hypertensive Individuals), which is not on this map. Cited by 86 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 12 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06612099 narecruitingnot on this mapstarted 2024, after this paper: background citation

Comparison of the Effects of Aerobic Exercise Training and Mat Pilates Exercise on Blood Pressure, Functional Capacity and Quality of Life in Hypertensive Individuals

TypeinterventionalSponsorBezmialem Vakif UniversityRan2024 to 2025Enrolled27ConditionsHypertensionArmsAerobic Exercise, Mat Pilates Exercise
3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 12 syntheses or guidelines pooled it, 157 citations in OpenAlex.

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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Gonzalo Saco-LedoBioenergy and Motion Analysis Laboratory National Research Center on Human Evolution (CENIEH) Burgos Spain.
Pedro L ValenzuelaDepartment of Systems Biology University of Alcalá Madrid Spain.
Gema Ruiz-HurtadoHypertension Unit and Cardiorenal Translational Laboratory Hospital 12 de Octubre Madrid Spain.
Luis M RuilopeHypertension Unit and Cardiorenal Translational Laboratory Hospital 12 de Octubre Madrid Spain.
Alejandro LuciaResearch Institute of the Hospital Universitario 12 de Octubre ('imas12') Madrid Spain.
Hospital Universitario 12 De Octubre · ESCentro Nacional de Investigación sobre la Evolución Humana · ESResearch Institute Hospital 12 de Octubre · ESUniversidad de Alcalá · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Although exercise training reduces office blood pressure (BP), scarcer evidence is available on whether these benefits also apply to ambulatory blood pressure (ABP), which is a stronger predictor of cardiovascular disease and mortality. The present study aims to assess the effects of exercise training on ABP in patients with hypertension based on evidence from randomized controlled trials. Methods and Results A systematic search of randomized controlled trials on the aforementioned topic was conducted in PubMed and Scopus (since inception to April 1, 2020). The mean difference between interventions (along with 95% CI) for systolic BP and diastolic BP was assessed using a random-effects model. Sub-analyses were performed attending to (1) whether participants were taking antihypertensive drugs and (2) exercise modalities. Fifteen studies (including 910 participants with hypertension) met the inclusion criteria. Interventions lasted 8 to 24 weeks (3-5 sessions/week). Exercise significantly reduced 24-hour (systolic BP, -5.4 mm Hg; [95% CI, -9.2 to -1.6]; diastolic BP, -3.0 mm Hg [-5.4 to -0.6]), daytime (systolic BP, -4.5 mm Hg [-6.6 to -2.3]; diastolic BP, -3.2 mm Hg [-4.8 to -1.5]), and nighttime ABP (systolic BP, -4.7 mm Hg [-8.4 to -1.0]; diastolic BP, -3.1 mm Hg [-5.3 to -0.9]). In separate analyses, exercise benefits on all ABP measures were significant for patients taking medication (all

Indexed as

AgedAntihypertensive AgentsBlood PressureBlood Pressure Monitoring, AmbulatoryCardiovascular DiseasesExerciseFemaleHeart Disease Risk FactorsHumansHypertensionMaleMiddle AgedRandomized Controlled Trials as TopicAntihypertensive Agentsblood pressurecardiovascular riskhypertensionphysical activity

Identifiers

PMID33280503
PMCPMC7955398
OpenAlexW3110715627

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.