Evidence map›Paper›PMID 33280491›Full record

ArticleJournal of neurotrauma2021

Autonomic Nervous System Activity during Refractory Rise in Intracranial Pressure.

Marta Fedriga, Andras Czigler, Nathalie Nasr, Frederick A Zeiler, Soojin Park, Joseph Donnelly, Vasilios Papaioannou, Shirin K Frisvold, Stephan Wolf, Frank Rasulo and 3 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

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  9. Association between temporal patterns of baroreflex sensitivity after traumatic brain injury and prognosis: a preliminary study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Marta FedrigaBrain Division of Neurosurgery, Department of Clinical Neurosciences, Physics Laboratory, University of Cambridge, Cambridge, United Kingdom.
Andras CziglerBrain Division of Neurosurgery, Department of Clinical Neurosciences, Physics Laboratory, University of Cambridge, Cambridge, United Kingdom.
Nathalie NasrUnitè de Neurologie Vasculaire, CHU de Toulouse, Universitè de Toulouse, Toulouse, France.
Frederick A ZeilerDivision of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Soojin ParkDepartment of Neurology, Division of Hospitalist and Critical Care Neurology, Columbia University, New York, New York, USA.
Joseph DonnellyDepartment of Anaesthesiology, University of Auckland, Aukland, New Zealand.
Vasilios PapaioannouUniversity Hospital of Alexandroupolis, Intensive Care Unit, Democritus University of Thrace, Alexandroupolis, Greece.
Shirin K FrisvoldDepartment of Intensive Care, University Hospital of North Norway, UiT The Arctic University of Norway, Tromso, Norway.
Stephan WolfDepartment of Neurosurgery, Charite Hospital, Berlin, Germany.
Frank RasuloDepartment of Anaesthesia, Critical Care and Emergency, Spedali Civili University Hospital, Brescia, Italy.
Marek SykoraDepartment of Neurology, St. John's Hospital Vienna, Medical Faculty, Sigmund Freud University, Vienna, Austria.
Peter SmielewskiBrain Division of Neurosurgery, Department of Clinical Neurosciences, Physics Laboratory, University of Cambridge, Cambridge, United Kingdom.
Marek CzosnykaBrain Division of Neurosurgery, Department of Clinical Neurosciences, Physics Laboratory, University of Cambridge, Cambridge, United Kingdom.
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITSigmund Freud University Vienna · ATUniversity of Cambridge · GBUniversity of Pecs · HU

Funding

Multiparametric Prediction of Vasospasm after Subarachnoid HemorrhageK01ES026833 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PARK, SOOJIN · 2015 to 2019
$1.1M
NIEHS NIH HHS K01 ES026833
6 · The paper itself

Abstract

Refractory intracranial hypertension (RIH) is a dramatic increase in intracranial pressure (ICP) that cannot be controlled by treatment. Recent reports suggest that the autonomic nervous system (ANS) activity may be altered during changes in ICP. Our study aimed to assess ANS activity during RIH and the causal relationship between rising in ICP and autonomic activity. We reviewed retrospectively 24 multicenter (Cambridge, Tromso, Berlin) patients in whom RIH developed as a pre-terminal event after acute brain injury (ABI). They were monitored with ICP, arterial blood pressure (ABP), and electrocardiography (ECG) using ICM+ software. Parameters reflecting autonomic activity were computed in time and frequency domain through the measurement of heart rate variability (HRV) and baroreflex sensitivity (BRS). Our results demonstrated that a rise in ICP was associated to a significant rise in HRV and BRS with a higher significance level in the high-frequency HRV (

Indexed as

AdultAgedAutonomic Nervous SystemBaroreflexBrain InjuriesFemaleHeart RateHumansIntracranial HypertensionMaleMiddle AgedRetrospective Studiesautonomic nervous systemGranger causalityrefractory intracranial hypertensionupper breakpoint of ICP

Identifiers

PMID33280491
PMCPMC8336253
OpenAlexW3111657706

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.