Evidence map›Paper›PMID 33280488›Full record

ArticleJournal of the American Heart Association2020

Cerebral Blood Flow and Cognitive Performance in Postural Tachycardia Syndrome: Insights from Sustained Cognitive Stress Test.

Rachel Wells, Varun Malik, Anthony G Brooks, Dominik Linz, Adrian D Elliott, Prashanthan Sanders, Amanda Page, Mathias Baumert, Dennis H Lau

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Faintly tired: a systematic review of fatigue in patients with orthostatic syncope.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022
    Pooled it
  3. Review
  4. Stroke volume reduction impairs cerebrovascular regulation through ETCOClinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  5. Article
  6. Long-COVID and postural orthostatic tachycardia syndrome: a preliminary comparison of neuropsychological performance.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Cognitive functioning in postural orthostatic tachycardia syndrome among different body positions: a prospective pilot study (POTSKog study).Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023
    Article
  11. Review
  12. Observational
  13. Article
  14. Article
  15. Article
  16. RT-QUiC in multiple system atrophy: the biomarker of the future? and other updates on recent autonomic research.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Rachel WellsCentre for Heart Rhythm Disorders The University of Adelaide Adelaide Australia.
Varun MalikCentre for Heart Rhythm Disorders The University of Adelaide Adelaide Australia.
Anthony G BrooksCentre for Heart Rhythm Disorders The University of Adelaide Adelaide Australia.
Dominik LinzCentre for Heart Rhythm Disorders The University of Adelaide Adelaide Australia.
Adrian D ElliottCentre for Heart Rhythm Disorders The University of Adelaide Adelaide Australia.
Prashanthan SandersCentre for Heart Rhythm Disorders The University of Adelaide Adelaide Australia.
Amanda PageCentre for Nutrition and Gastrointestinal Diseases The University of Adelaide Adelaide Australia.
Mathias BaumertCentre for Heart Rhythm Disorders The University of Adelaide Adelaide Australia.
Dennis H LauCentre for Heart Rhythm Disorders The University of Adelaide Adelaide Australia.
Royal Adelaide Hospital · AUThe University of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background The physiology underlying "brain fog" in the absence of orthostatic stress in postural tachycardia syndrome (POTS) remains poorly understood. Methods and Results We evaluated cognitive and hemodynamic responses (cardiovascular and cerebral: heart rate, blood pressure, end-tidal carbon dioxide, and cerebral blood flow velocity (CBFv) in the middle cerebral artery at baseline, after initial cognitive testing, and after (30-minutes duration) prolonged cognitive stress test (PCST) whilst seated; as well as after 5-minute standing in consecutively enrolled participants with POTS (n=22) and healthy controls (n=18). Symptom severity was quantified with orthostatic hypotensive questionnaire at baseline and end of study. Subjects in POTS and control groups were frequency age- and sex-matched (29±11 versus 28±13 years; 86 versus 72% women, respectively; both

Indexed as

AdolescentAdultBlood PressureCarbon DioxideCase-Control StudiesCerebrovascular CirculationCognitive DysfunctionFemaleHeart RateHemodynamicsHumansMaleMiddle Cerebral ArteryNeuropsychological TestsOrthostatic IntolerancePostural Orthostatic Tachycardia SyndromeCarbon Dioxidecerebral blood flowcognitive dysfunctionorthostatic intolerancepostural tachycardia syndrometranscranial doppler

Identifiers

PMID33280488
PMCPMC7955388
OpenAlexW3112020768

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.