ArticleCancer medicine2021
A practical nomogram and risk stratification system predicting the cancer-specific survival for patients with early hepatocellular carcinoma.
Article in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Construction of webZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Trial
- Construction and validation of a SEER-based prognostic nomogram for young and middle-aged males patients with hepatocellular carcinoma.Journal of cancer research and clinical oncology · 2023Trial
- Establishment and validation of a prognostic nomogram for patients with early-onset stage I-II colon cancer.World journal of surgical oncology · 2023Trial
- A Web-Based Prediction Model for Cancer-Specific Survival of Elderly Patients With Early Hepatocellular Carcinoma: A Study Based on SEER Database.Frontiers in public health · 2021Trial
- Personalizing Postoperative Surveillance: A Risk-Stratified Predictive Model for Recurrence of Gastrointestinal Neuroendocrine Neoplasms.Journal of gastrointestinal cancer · 2026Article
- Clinical model for predicting overall survival outcomes in individuals with hepatocellular carcinoma: a retrospective cohort analysis.Journal of gastrointestinal oncology · 2026Article
- Establishment of a prognostic nomogram for intrahepatic cholangiocarcinoma patients receiving chemotherapy: a SEER-based study.Journal of gastrointestinal oncology · 2025Article
- Competing risk analysis of surgical resectionTranslational cancer research · 2025Article
- Identification of Patients with Early-Stage Hepatocellular Carcinoma Benefiting from Neoadjuvant Chemotherapy-A SEER-Based Study.Journal of gastrointestinal cancer · 2025Article
- Deep learning models for predicting the survival of patients with hepatocellular carcinoma based on a surveillance, epidemiology, and end results (SEER) database analysis.Scientific reports · 2024Article
- Development of a machine learning-based model to predict prognosis of alpha-fetoprotein-positive hepatocellular carcinoma.Journal of translational medicine · 2024Article
- Development and validation of a clinical prediction model for the risk of distal metastasis in intrahepatic cholangiocarcinoma: a real-world study.BMC gastroenterology · 2024Article
- Conditional survival probability of distant-metastatic hepatocellular carcinoma: A population-based study.World journal of gastrointestinal oncology · 2023Article
- Article
- How to use the Surveillance, Epidemiology, and End Results (SEER) data: research design and methodology.Military Medical Research · 2023Review
- Transhepatectomy combined with arterial chemoembolization and transcatheter arterial chemoembolization in the treatment of hepatocellular carcinoma: a clinical prognostic analysis.BMC gastroenterology · 2023Article
- Prognostic factors and survival prediction in hepatocellular carcinoma: development and validation of a novel nomogram based on the SEER database.Journal of gastrointestinal oncology · 2023Article
- A propensity score matching study on survival benefits of radiotherapy in patients with inoperable hepatocellular carcinoma.Scientific reports · 2023Article
- Article
- A nomogram for individually predicting the overall survival in colonic adenocarcinoma patients presenting with perineural invasion: a population study based on SEER database.Frontiers in oncology · 2023Article
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7 authors.
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Abstract
backgroundOur purpose was to establish and validate a nomogram model in early hepatocellular carcinoma (HCC) patients for predicting the cancer-specific survival (CSS).
methodsWe extracted eligible data of relevant patients between 2010 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database. Further, we divided all patients into two groups (training and validation cohorts) at random (7:3). Nomogram was established using effective risk factors based on univariate and multivariate analysis. The effective performance of nomogram was evaluated using concordance index (C-index), calibration plots, decision curve analysis (DCA), and receiver operating characteristic curve (ROC).
resultsWe selected 3620 patients with early HCC including the training cohort (70%, 2536) and the validation cohort (30%, 1084). The nomogram-related C-indexes were 0.755 (95% CI: 0.739-0.771) and 0.737 (95% CI: 0.712-0.762), in the training and validation cohorts, respectively. The calibration plots showed good consistency of 3-and 5-year CSS between the actual observation and the nomogram prediction. The 3-, 5-year DCA curves also indicated that the nomogram has excellent clinical utility. The 3-, 5-year area under curve (AUC) of ROC in the training cohort were 0.783, 0.779, respectively, and 0.767, 0.766 in the validation cohort, respectively. With the establishment of nomogram, a risk stratification system was also established that could divide all patients into three risk groups, and the CSS in different groups (i.e., low risk, intermediate risk, and high risk) had a good regional division.
conclusionsWe developed a practical nomogram in early HCC patients for predicting the CSS, and a risk stratification system follow arisen, which provided an applicable tool for clinical management.
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