ArticleThe EMBO journal2021
BIC1 acts as a transcriptional coactivator to promote brassinosteroid signaling and plant growth.
Article in The EMBO journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 38 citations in OpenAlex.
- Expanding the triangle of U: comparative analysis of the Hirschfeldia incana genome provides insights into chromosomal evolution, phylogenomics and high photosynthesis-related traits.Annals of botany · 2026Article
- bZIP factors of the Unfolded Protein Response interact with PIF4 to promote thermomorphogenesis.Nature communications · 2025Article
- GmBSK1-GmGSK1-GmBES1.5 regulatory module controls heat tolerance in soybean.Journal of advanced research · 2025Article
- Genome-wide screening of mitogen-activated protein kinase (MAPK) gene family and expression profile under heavy metal stress in Solanum lycopersicum.Biotechnology letters · 2025Article
- Applying traditional and machine learning-based GWAS approaches for marker-trait identification in wheat.Frontiers in plant science · 2025Article
- Interactions between Brassinosteroids and Strigolactones in Alleviating Salt Stress in Maize.International journal of molecular sciences · 2024Article
- Interaction of the Transcription Factors BES1/BZR1 in Plant Growth and Stress Response.International journal of molecular sciences · 2024Review
- The BAS chromatin remodeler determines brassinosteroid-induced transcriptional activation and plant growth in Arabidopsis.Developmental cell · 2024Article
- Physiology, genomics, and evolutionary aspects of desert plants.Journal of advanced research · 2024Review
- GSK3 phosphorylates and regulates the Green Revolution protein Rht-B1b to reduce plant height in wheat.The Plant cell · 2023Article
- BIN2 phosphorylates the Thr280 of CO to restrict its function in promotingFrontiers in plant science · 2023Article
- Light signaling-mediated growth plasticity in Arabidopsis grown under high-temperature conditions.Stress biology · 2022Review
- ERF49 mediates brassinosteroid regulation of heat stress tolerance in Arabidopsis thaliana.BMC biology · 2022Article
- Full-Length Transcriptome Sequencing Reveals the Impact of Cold Stress on Alternative Splicing in Quinoa.International journal of molecular sciences · 2022Article
- Signaling Mechanisms by Arabidopsis Cryptochromes.Frontiers in plant science · 2022Review
- Integration of Light and Brassinosteroid Signaling during Seedling Establishment.International journal of molecular sciences · 2021Review
- PIF4 and PIF4-Interacting Proteins: At the Nexus of Plant Light, Temperature and Hormone Signal Integrations.International journal of molecular sciences · 2021Review
- BIC1 acts as a transcriptional coactivator to promote brassinosteroid signaling and plant growth.The EMBO journal · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The BRASSINAZOLE-RESISTANT 1 (BZR1) transcription factor family plays an essential role in plant brassinosteroid (BR) signaling, but the signaling mechanism through which BZR1 and its homologs cooperate with certain coactivators to facilitate transcription of target genes remains incompletely understood. In this study, we used an efficient protein interaction screening system to identify blue-light inhibitor of cryptochromes 1 (BIC1) as a new BZR1-interacting protein in Arabidopsis thaliana. We show that BIC1 positively regulates BR signaling and acts as a transcriptional coactivator for BZR1-dependent activation of BR-responsive genes. Simultaneously, BIC1 interacts with the transcription factor PIF4 to synergistically and interdependently activate expression of downstream genes including PIF4 itself, and to promote plant growth. Chromatin immunoprecipitation assays demonstrate that BIC1 and BZR1/PIF4 interdependently associate with the promoters of common target genes. In addition, we show that the interaction between BIC1 and BZR1 is evolutionally conserved in the model monocot plant Triticum aestivum (bread wheat). Together, our results reveal mechanistic details of BR signaling mediated by a transcriptional activation module BIC1/BZR1/PIF4 and thus provide new insights into the molecular mechanisms underlying the integration of BR and light signaling in plants.
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