ArticleEuropean heart journal. Cardiovascular Imaging2021
Mitral annulus disjunction is associated with adverse outcome in Marfan and Loeys-Dietz syndromes.
Article in European heart journal. Cardiovascular Imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Association of Cardiovascular Events Between Mitral Annular Disjunction and Left Atrial Reservoir Strain in Barlow's Disease.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Mitral Annular Disjunction: Epidemiology, Diagnostic Methods, Prognosis, and Novel Implications.Journal of cardiovascular development and disease · 2025Review
- Advances in Cardiovascular Multimodality Imaging in Patients with Marfan Syndrome.Diagnostics (Basel, Switzerland) · 2025Review
- Mitral Annular Disjunction in Heritable Thoracic Aortic Disease: Insights From the Montalcino Aortic Consortium.Journal of the American Heart Association · 2024Article
- Mitral annular disjunction and its progression during childhood in Marfan syndrome.European heart journal. Cardiovascular Imaging · 2024Article
- Mitral Annular Disjunction: An Under-Recognized Entity in Pediatrics.JACC. Case reports · 2024Article
- What Do We Know So Far About Ventricular Arrhythmias and Sudden Cardiac Death Prediction in the Mitral Valve Prolapse Population? Could Biomarkers Help Us Predict Their Occurrence?Current cardiology reports · 2024Review
- Diagnosis and treatment of cardiovascular disease in patients with heritable connective tissue disorders or heritable thoracic aortic diseases.Cardiovascular intervention and therapeutics · 2024Review
- Mitral annular disjunction; how accurate are we? A cardiovascular MRI study defining risk.International journal of cardiology. Heart & vasculature · 2023Article
- Mitral Annular Disjunction: Review of an Increasingly Recognized Mitral Valve Entity.Radiology. Cardiothoracic imaging · 2023Review
- Case report: Aborted sudden cardiac death as a first presentation of severe mitral annulus disjunction-a case series and review of the literature.Frontiers in cardiovascular medicine · 2023Article
- Arrhythmic mitral valve prolapse in 2023: Evidence-based update.Frontiers in cardiovascular medicine · 2023Review
- EHRA expert consensus statement on arrhythmic mitral valve prolapse and mitral annular disjunction complex in collaboration with the ESC Council on valvular heart disease and the European Association of Cardiovascular Imaging endorsed cby the Heart Rhythm Society, by the Asia Pacific Heart Rhythm Society, and by the Latin American Heart Rhythm Society.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2022Article
- Does Anatomic Phenotype of Mitral Annular Disjunction Impact Survival? An Autopsy-Based Retrospective Study.Journal of cardiovascular development and disease · 2021Article
- Arrhythmic Mitral Valve Prolapse and Mitral Annulus Disjunction in Heritable Aortic Disease.CJC open · 2021Article
- Association of Mitral Annular Disjunction With Cardiovascular Outcomes Among Patients With Marfan Syndrome.JAMA cardiology · 2021Article
- Marfan syndrome.Nature reviews. Disease primers · 2021Review
- Mitral annular disjunction in patients with severe aortic stenosis: Extent and reproducibility of measurements with computed tomography.European journal of radiology open · 2021Article
- Mitral annular disjunction in Marfan syndrome: a multicenter cardiovascular magnetic resonance study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceArticle
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsWe aimed to assess the prevalence of mitral annulus disjunction (MAD) and to explore the association with aortic disease and mitral valve surgery in patients with Marfan syndrome (MFS) and Loeys-Dietz syndrome (LDS). METHODS AND
resultsWe included consecutive MFS patients fulfilling Revised Ghent Criteria and LDS patients fulfilling Loeys-Dietz Revised Nosology. MAD was identified by echocardiography and was quantified as the longitudinal distance from the ventricular myocardium to the hinge point of the posterior mitral leaflet. Aortic events were defined as aortic dissection or prophylactic aortic surgery. We recorded the need of mitral valve surgery including mitral valve repair or replacement. We included 168 patients (103 with MFS and 65 with LDS). The prevalence of MAD was 41%. MAD was present in all age groups. Aortic events occurred in 112 (67%) patients (27 with dissections and 85 with prophylactic surgical interventions). Patients with MAD were younger at aortic event than those without MAD (log rank = 0.02) Patients with aortic events had greater MAD distance in posterolateral wall [8 (7-10) mm vs. 7 (6-8) mm, P = 0.04]. Mitral events occurred more frequently in patients with MAD (P < 0.001).
conclusionMAD was highly prevalent in patients with MFS and LDS. MAD was a marker of severe disease including aortic events at younger age and need of mitral valve surgery. Screening patients with MFS an LDS for MAD may provide prognostic information and may be relevant in planning surgical intervention. Detection of MAD in patients with MFS and LDS may infer closer clinical follow-up from younger age.
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