ArticleCerebral cortex (New York, N.Y. : 1991)2021
Hierarchical Complexity of the Macro-Scale Neonatal Brain.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Neonatal amygdala microstructure and structural connectivity are associated with autistic traits at 2 years of age.Developmental cognitive neuroscience · 2026Article
- Relative Strength Variability Measures for Brain Structural Connectomes and Their Relationship With Cognitive Functioning.Human brain mapping · 2025Article
- Brain 3T magnetic resonance imaging in neonates: features and incidental findings from a research cohort enriched for preterm birth.Archives of disease in childhood. Fetal and neonatal edition · 2024Article
- Article
- Predicting 2-year neurodevelopmental outcomes in preterm infants using multimodal structural brain magnetic resonance imaging with local connectivity.Scientific reports · 2024Article
- Feature similarity gradients detect alterations in the neonatal cortex associated with preterm birth.Human brain mapping · 2024Article
- Revealing brain's cognitive process deeply: a study of the consistent EEG patterns of audio-visual perceptual holistic.Frontiers in human neuroscience · 2024Article
- Association of Preterm Birth and Socioeconomic Status With Neonatal Brain Structure.JAMA network open · 2023Article
- Structural connectivity of the sensorimotor network within the non-lesioned hemisphere of children with perinatal stroke.Scientific reports · 2022Article
- Abnormal Functional Hierarchies of EEG Networks in Familial and Sporadic Prodromal Alzheimer's Disease During Visual Short-Term Memory Binding.Frontiers in neuroimaging · 2022Article
- Typical and disrupted brain circuitry for conscious awareness in full-term and preterm infants.Brain communications · 2022Article
- Brain network reorganisation and spatial lesion distribution in systemic lupus erythematosus.Lupus · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
The human adult structural connectome has a rich nodal hierarchy, with highly diverse connectivity patterns aligned to the diverse range of functional specializations in the brain. The emergence of this hierarchical complexity in human development is unknown. Here, we substantiate the hierarchical tiers and hierarchical complexity of brain networks in the newborn period, assess correspondences with hierarchical complexity in adulthood, and investigate the effect of preterm birth, a leading cause of atypical brain development and later neurocognitive impairment, on hierarchical complexity. We report that neonatal and adult structural connectomes are both composed of distinct hierarchical tiers and that hierarchical complexity is greater in term born neonates than in preterms. This is due to diversity of connectivity patterns of regions within the intermediate tiers, which consist of regions that underlie sensorimotor processing and its integration with cognitive information. For neonates and adults, the highest tier (hub regions) is ordered, rather than complex, with more homogeneous connectivity patterns in structural hubs. This suggests that the brain develops first a more rigid structure in hub regions allowing for the development of greater and more diverse functional specialization in lower level regions, while connectivity underpinning this diversity is dysmature in infants born preterm.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.