SynthesisOphthalmic research2021
Association of Tumor Necrosis Factor-Alpha-308 G/A and -238 G/A Polymorphism with Diabetic Retinopathy: A Systematic Review and Updated Meta-Analysis.
Synthesis in Ophthalmic research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Associations of genetic factors with vascular diabetes complications: an umbrella review.Journal of global health · 2025Pooled it
- Frequency of Tumor Necrosis Factor-α, Interleukin-6, and Interleukin-10 Gene Polymorphisms in Mexican Patients with Diabetic Retinopathy and Diabetic Kidney Disease.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Article
- Correlation of tumor necrosis factor-α and interleukin-1 single-nucleotide polymorphisms with the risk of migraine development.Frontiers in genetics · 2025Article
- Elevated aqueous TNF-α levels are associated with more severe functional and anatomic findings in eyes with diabetic macular oedema.Clinical & experimental ophthalmology · 2024Article
- Is TNF alpha a mediator in the co-existence of malaria and type 2 diabetes in a malaria endemic population?Frontiers in immunology · 2023Article
- The Role of Adaptive Immunity in Diabetic Retinopathy.Journal of clinical medicine · 2022Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMounting evidence has suggested that tumor necrosis factor-alpha (TNF-α) can promote the development of diabetic retinopathy (DR), and TNF-α gene variants may influence DR risk. However, the results are quite different.
objectivesTo comprehensively address this issue, we performed the meta-analysis to evaluate the association of TNF-α-308 G/A and -238 G/A polymorphism with DR.
methodData were retrieved in a systematic manner and analyzed using STATA Statistical Software. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. Allelic and genotypic comparisons between cases and controls were evaluated.
resultsFor the TNF-α-308 G/A polymorphism, overall analysis suggested a marginal association with DR (the OR [95% CI] of [GA vs. GG], [GA + AA] vs. GG, and [A vs. G] are 1.21 [1.04, 1.41], 1.20 [1.03, 1.39], and 1.14 [1.01, 1.30], respectively). And the subgroup analysis indicated an enhanced association among the European population. For the TNF-α-238 G/A polymorphism, there was a mild correlation in the entire group (the OR [95% CI] of [GA vs. GG] is 1.55 [1.14, 2.11]), which was strengthened among the Asian population.
conclusionThe meta-analysis suggested that -308 A and -238 A allele in TNF-α gene potentially increased DR risk and showed a discrepancy in different ethnicities.
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