Evidence map›Paper›PMID 33279717›Full record

ArticleBrain stimulation

Stimulation of the right entorhinal white matter enhances visual memory encoding in humans.

Emily A Mankin, Zahra M Aghajan, Peter Schuette, Michelle E Tran, Natalia Tchemodanov, Ali Titiz, Güldamla Kalender, Dawn Eliashiv, John Stern, Shennan A Weiss and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 45 citations in OpenAlex.

  1. Trial
  2. Article
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  4. Review
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  6. Article
  7. Exploring individual differences in amygdala-mediated memory modulation.Cognitive, affective & behavioral neuroscience · 2025
    Article
  8. Article
  9. Article
  10. Cortical and white matter substrates supporting visuospatial working memory.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Article
  11. Article
  12. Article
  13. Hippocampal Functions Modulate Transfer-Appropriate Cortical Representations Supporting Subsequent Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Electrical Wada for pre-surgical memory testing: a case report.Epileptic disorders : international epilepsy journal with videotape · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 2 countries.

Emily A MankinDepartment of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, 300 Stein Plaza, Los Angeles, CA, 90095, USA.
Zahra M AghajanDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA, 90095, USA.
Peter SchuetteDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA, 90095, USA; Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA, 90095, USA.
Michelle E TranDepartment of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, 300 Stein Plaza, Los Angeles, CA, 90095, USA.
Natalia TchemodanovDepartment of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, 300 Stein Plaza, Los Angeles, CA, 90095, USA.
Ali TitizDepartment of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, 300 Stein Plaza, Los Angeles, CA, 90095, USA.
Güldamla KalenderDepartment of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, 300 Stein Plaza, Los Angeles, CA, 90095, USA.
Dawn EliashivDepartment of Neurology, University of California, Los Angeles, 710 Westwood Plaza, Los Angeles, CA, 90095, USA.
John SternDepartment of Neurology, University of California, Los Angeles, 710 Westwood Plaza, Los Angeles, CA, 90095, USA.
Shennan A WeissDepartment of Neurology, University of California, Los Angeles, 710 Westwood Plaza, Los Angeles, CA, 90095, USA.
Dylan KirschDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA, 90095, USA.
Barbara KnowltonDepartment of Psychology, University of California, Los Angeles, 502 Portola Plaza, Los Angeles, CA, 90095, USA.
Itzhak FriedDepartment of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, 300 Stein Plaza, Los Angeles, CA, 90095, USA; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA, 90095, USA; Functional Neurosurgery Unit, Tel-Aviv Medical Center and Sackler School of Medicine, Tel-Aviv University, P.O.B 39040 Ramat Aviv, Tel-Aviv, 69978, Israel.
Nanthia SuthanaDepartment of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, 300 Stein Plaza, Los Angeles, CA, 90095, USA; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA, 90095, USA; Department of Psychology, University of California, Los Angeles, 502 Portola Plaza, Los Angeles, CA, 90095, USA; Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA, 90095, USA. Electronic address: nanthia@ucla.edu.
University of California, Los Angeles · US

Funding

Neurostimulation and Recording of Real World Spatial Navigation in HumansU01NS117838 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUTHANA, NANTHIA A · 2020 to 2024
$5.3M
Mechanisms of Memory Enhancement by Deep Brain Stimulation in HumansR01NS084017 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FRIED, ITZHAK · 2013 to 2022
$4.7M
Neurostimulation and Recording of Real World Spatial Navigation in HumansU01NS103802 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUTHANA, NANTHIA A · 2017 to 2019
$3.4M
NEURONAL CORRELATES OF MEMORY IN THE HUMAN TEMPORAL LOBER01NS033221 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FRIED, ITZHAK · 1996 to 2011
$2.9M
Training Program in Neural MicrocircuitsT32NS058280 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FELDMAN, JACK L · 2007 to 2017
$2.4M
Memory consolidation during sleep studied by direct neuronal recording and stimulation inside human brainU01NS108930 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FRIED, ITZHAK · 2018 to 2019
$1.9M
Neuronal Correlates of Memory in the Human Temporal LobeR56NS033221 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FRIED, ITZHAK · 2012 to 2012
$385k
NINDS NIH HHS R01 NS033221NINDS NIH HHS R01 NS084017NINDS NIH HHS R56 NS033221NINDS NIH HHS T32 NS058280NINDS NIH HHS U01 NS103802NINDS NIH HHS U01 NS108930NINDS NIH HHS U01 NS117838
6 · The paper itself

Abstract

backgroundWhile deep brain stimulation has been successful in treating movement disorders, such as in Parkinson's disease, its potential application in alleviating memory disorders is inconclusive. OBJECTIVE/HYPOTHESIS: We investigated the role of the location of the stimulating electrode on memory improvement and hypothesized that entorhinal white versus gray matter stimulation would have differential effects on memory.

methodsIntracranial electrical stimulation was applied to the entorhinal area of twenty-two participants with already implanted electrodes as they completed visual memory tasks.

resultsWe found that stimulation of right entorhinal white matter during learning had a beneficial effect on subsequent memory, while stimulation of adjacent gray matter or left-sided stimulation was ineffective. This finding was consistent across three different visually guided memory tasks.

conclusionsOur results highlight the importance of precise stimulation site on modulation of human hippocampal-dependent memory and suggest that stimulation of afferent input into the right hippocampus may be an especially promising target for enhancement of visual memory.

Indexed as

White MatterEntorhinal CortexHippocampusHumansMemoryTemporal LobeDeclarative memoryDeep brain stimulationEntorhinal cortexHippocampusIntracranial electrical stimulationWhite matter

Identifiers

PMID33279717
PMCPMC7855810
OpenAlexW3110316002

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.