ArticleActa biomaterialia2021
Constitutive modeling using structural information on collagen fiber direction and dispersion in human superficial femoral artery specimens of different ages.
Article in Acta biomaterialia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Nonlinear Microscopy of ECM Remodeling in Renal and Vascular Tissues: A Systematic Review Integrating Human AVF Imaging.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Critical Systematic Review of 3D Bioprinting in Biomedicine.International journal of molecular sciences · 2025Pooled it
- EXPERIMENTAL CHARACTERIZATION OF BALLOON ANGIOPLASTY IN HUMAN FEMOROPOPLITEAL ARTERIES WITH DIFFERENT CALCIUM BURDENS.bioRxiv : the preprint server for biology · 2025Article
- Differential effects of demographics and risk factors on the nonlinear orthotropic mechanical properties of human femoropopliteal arteries.Biomechanics and modeling in mechanobiology · 2025Article
- Three-dimensional quantitative evaluation of hypertension-induced aortic fibre remodelling based on multiphoton microscopy: a cross-age perspective.Royal Society open science · 2025Article
- Large animal model of controlled peripheral artery calcification.Acta biomaterialia · 2025Article
- Characterization of mechanical damage and viscoelasticity on aortas from guinea pigs subjected to hypoxia.Scientific reports · 2025Article
- Effect of melatonin on passive, ex-vivo biomechanical behavior of lamb esophagus.Scientific reports · 2025Article
- Biomechanics of soft biological tissues and organs, mechanobiology, homeostasis and modelling.Journal of the Royal Society, Interface · 2025Review
- A viscoelastic constitutive framework for aging muscular and elastic arteries.Acta biomaterialia · 2024Article
- Layer-specific biomechanical and histological properties of normal and dissected human ascending aortas.Heliyon · 2024Article
- Experimental Protocols to Test Aortic Soft Tissues: A Systematic Review.Bioengineering (Basel, Switzerland) · 2024Review
- Integrating muscle fiber orientation from visible human data into radiotherapy target volumes.Physics in medicine and biology · 2024Article
- An optimized differential evolution algorithm for constitutive model fitting of arteries.Acta mechanica · 2024Article
- Mechanical, structural, and morphological differences in the iliac arteries.Journal of the mechanical behavior of biomedical materials · 2024Article
- Structural and Mechanical Properties of Human Superficial Femoral and Popliteal Arteries.Annals of biomedical engineering · 2024Review
- Mechanical, structural, and physiologic differences between above and below-knee human arteries.Acta biomaterialia · 2024Article
- A viscoelastic constitutive model for human femoropopliteal arteries.Acta biomaterialia · 2023Article
- Medical Image-Based Computational Fluid Dynamics and Fluid-Structure Interaction Analysis in Vascular Diseases.Frontiers in bioengineering and biotechnology · 2022Review
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Arterial mechanics plays an important role in vascular pathophysiology and repair, and advanced imaging can inform constitutive models of vascular behavior. We have measured the mechanical properties of 14 human superficial femoral arteries (SFAs) (age 12-70, mean 48±19 years) using planar biaxial extension, and determined the preferred collagen fiber direction and dispersion using multiphoton microscopy. The collagen fiber direction and dispersion were evaluated using second-harmonic generation imaging and modeled using bivariate von Mises distributions. The microstructures of elastin and collagen were assessed using two-photon fluorescence imaging and conventional bidirectional histology. The mechanical and structural data were used to describe the SFA mechanical behavior using two- and four-fiber family invariant-based constitutive models. Older SFAs were stiffer and mechanically more nonlinear than younger specimens. In the adventitia, collagen fibers were undulated and diagonally-oriented, while in the media, they were straight and circumferentially-oriented. The media was rich in collagen that surrounded the circumferentially-oriented smooth muscle cells, and the elastin was present primarily in the internal and external elastic laminae. Older SFAs had a more circumferential collagen fiber alignment, a decreased circumferential-radial fiber dispersion, but the same circumferential-longitudinal fiber dispersion as younger specimens. Both the two- and the four-fiber family constitutive models were able to capture the experimental data, and the fits were better for the four-fiber family formulation. Our data provide additional details on the SFA intramural structure and inform structurally-based constitutive models.
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