Evidence map›Paper›PMID 33279641›Full record

ArticleBehavioural brain research2021

The CUL3/neddylation inhibitor MLN4924 reduces ethanol-induced locomotor sensitization and inflammatory pain allodynia in mice.

Zhong Ding, Gregory T Knipp, Richard M van Rijn, Julia A Chester, Val J Watts

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Neddylation steers the fate of cellular receptors.Experimental & molecular medicine · 2024
    Review
  3. KCTD1 regulation of Adenylyl cyclase type 5 adjusts striatal cAMP signaling.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Article
  5. Review
  6. Paraquat exposure produces sex-dependent reduction in binge-like alcohol drinking in high alcohol-preferring mice.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhong DingDept of Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA.
Gregory T KnippDept of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN, 47907, USA; Purdue Institute for Drug Discovery, Purdue University, West Lafayette, IN, 47907, USA.
Richard M van RijnDept of Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA; Purdue Institute for Drug Discovery, Purdue University, West Lafayette, IN, 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, 47907, USA.
Julia A ChesterPurdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, 47907, USA; Dept of Psychological Sciences, Purdue University, West Lafayette, IN, 47907, USA.
Val J WattsDept of Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA; Purdue Institute for Drug Discovery, Purdue University, West Lafayette, IN, 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, 47907, USA. Electronic address: wattsv@purdue.edu.
Purdue University West Lafayette · US

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
G-protein-, beta-arrestin- and ERK-signaling in alcohol use- and anxiety-disordersR01AA025368 · NIAAA · PURDUE UNIVERSITY · PI CHESTER, JULIA ANN · 2017 to 2021
$1.7M
Understanding adaptive signaling of neuronal adenyly cyclases using siRNAR33MH101673 · NIMH · PURDUE UNIVERSITY · PI WATTS, VAL J · 2015 to 2016
$889k
The influence of alcohol on the metastatic dormancy of breast cancerR21AA026675 · NIAAA · PURDUE UNIVERSITY · PI VAN RIJN, RICHARD M., WENDT, MICHAEL KEITH · 2018 to 2019
$280k
Understanding adaptive signaling of neuronal adenyly cyclases using siRNAR21MH101673 · NIMH · PURDUE UNIVERSITY · PI WATTS, VAL J · 2014 to 2014
$261k
Development of G-protein biased delta opioid receptor agonist with analgesic potencyR03DA045897 · NIDA · PURDUE UNIVERSITY · PI VAN RIJN, RICHARD M. · 2018 to 2019
$149k
NCATS NIH HHS UL1 TR002529NIAAA NIH HHS R01 AA025368NIAAA NIH HHS R21 AA026675NIDA NIH HHS R03 DA045897NIMH NIH HHS R21 MH101673NIMH NIH HHS R33 MH101673
6 · The paper itself

Abstract

Heterologous sensitization of adenylyl cyclase (AC) is defined by an enhanced cAMP response following persistent activation of Gα

Indexed as

NEDD8 ProteinAlcoholismAnimalsCentral Nervous System DepressantsCentral Nervous System SensitizationCullin ProteinsCyclopentanesDisease Models, AnimalEnzyme InhibitorsEthanolHyperalgesiaInflammationLocomotionMaleMiceMice, Inbred BALB CCentral Nervous System DepressantsCul3 protein, mouseCullin ProteinsCyclopentanesEnzyme InhibitorsEthanolNEDD8 ProteinpevonedistatPyrimidinesAdenylyl cyclaseAlcoholHeterologous sensitizationInflammatory painLocomotor sensitizationMLN4924NeddylationSubstance use disorder

Identifiers

PMID33279641
PMCPMC7855618
OpenAlexW3110613611

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.