Evidence map›Paper›PMID 33279514›Full record

ArticleToxicology and applied pharmacology2021

Modulation of PARP activity by Monomethylarsonous (MMA

Sebastian Medina, Xixi Zhou, Fredine T Lauer, Haikun Zhang, Ke Jian Liu, Johnnye Lewis, Scott W Burchiel

Open access · greenAbstract readComparative Study
In one paragraph

Article in Toxicology and applied pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sebastian MedinaDepartment of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM, USA; Department of Biology, New Mexico Highlands University, Las Vegas, NM, USA.
Xixi ZhouDepartment of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM, USA.
Fredine T LauerDepartment of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM, USA.
Haikun ZhangDepartment of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM, USA.
Ke Jian LiuDepartment of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM, USA.
Johnnye LewisDepartment of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM, USA.
Scott W BurchielDepartment of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM, USA. Electronic address: sburchiel@salud.unm.edu.
University of New Mexico · USNew Mexico Highlands University · US

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
UNM Metals Exposure and Toxicity Assessment on tribal Lands in the Southwest (METALS) Superfund Research ProgramP42ES025589 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CERRATO, JOSE MANUEL · 2017 to 2025
$16.4M
The Role of Biotransformation in Arsenic-Induced HematotoxicityR01ES029369 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LIU, KE JIAN · 2018 to 2022
$1.8M
NCI NIH HHS P30 CA118100NIEHS NIH HHS P42 ES025589NIEHS NIH HHS R01 ES029369
6 · The paper itself

Abstract

Arsenic exposure is well established to impair the function of zinc finger proteins, including PARP-1. Previous studies from our lab show that early developing T cells in the thymus are very sensitive to arsenite (As

Indexed as

AnimalsCells, CulturedDose-Response Relationship, DrugHeme Oxygenase-1MaleMembrane ProteinsMiceMice, Inbred C57BLOrganometallic CompoundsOxidative StressPoly (ADP-Ribose) Polymerase-1Poly(ADP-ribose) Polymerase InhibitorsThymus GlandHeme Oxygenase-1Hmox1 protein, mouseMembrane Proteinsmonomethylarsonous acidOrganometallic CompoundsParp1 protein, mousePoly (ADP-Ribose) Polymerase-1Poly(ADP-ribose) Polymerase Inhibitorsuranyl acetateArsenicImmunotoxicityMetalsMonomethylarsonous Acid (MMA(+3))Poly-ADP-Ribose Polymerase-1 (PARP-1)T CellsUranium

Identifiers

PMID33279514
PMCPMC7855914
OpenAlexW3107666834

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.