Evidence map›Paper›PMID 33279280›Full record

ReviewTrends in biotechnology2021

In Situ 3D Printing: Opportunities with Silk Inks.

Francesca Agostinacchio, Xuan Mu, Sandra Dirè, Antonella Motta, David L Kaplan

Abstract readReview
In one paragraph

Review in Trends in biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Material-Assisted Strategies for Osteochondral Defect Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. 3D Bioprinting in Limb Salvage Surgery.Journal of functional biomaterials · 2024
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Silk fibroin-based inks forBioactive materials · 2024
    Article
  16. Silk fibroin-based scaffolds for tissue engineering.Frontiers in bioengineering and biotechnology · 2024
    Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Francesca AgostinacchioDepartment of Industrial Engineering, University of Trento, Via Sommarive 9, 38123 Trento, Italy; BIOTech Research Center and European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Trento, via Delle Regole 101, Trento 38123, Italy.
Xuan MuDepartment of Biomedical Engineering Tufts University Medford, MA 02155, USA.
Sandra DirèDepartment of Industrial Engineering, University of Trento, Via Sommarive 9, 38123 Trento, Italy; 'Klaus Muller' Magnetic Resonance Laboratory, Department of Industrial Engineering, University of Trento, Via Sommarive 9, 38123 Trento, Italy.
Antonella MottaDepartment of Industrial Engineering, University of Trento, Via Sommarive 9, 38123 Trento, Italy; BIOTech Research Center and European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Trento, via Delle Regole 101, Trento 38123, Italy.
David L KaplanDepartment of Biomedical Engineering Tufts University Medford, MA 02155, USA. Electronic address: david.kaplan@tufts.edu.

Funding

Tissue Engineering Resource Center: TTDP41EB027062 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gordana Vunjak-Novakovic · 2019 to 2026
$12.6M
Models to Predict Protein Biomaterial PerformanceU01EB014976 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI BUEHLER, MARKUS J., KAPLAN, DAVID L. · 2012 to 2020
$5.2M
Injectable Gels for Tissue AugmentationR01EB021264 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI HOUSE, MICHAEL DOUGLAS, KAPLAN, DAVID L. · 2016 to 2019
$1.4M
NIBIB NIH HHS P41 EB027062NIBIB NIH HHS R01 EB021264NIBIB NIH HHS U01 EB014976
6 · The paper itself

Abstract

In situ 3D printing is an emerging technique designed for patient-specific needs and performed directly in the patient's tissues in the operating room. While this technology has progressed rapidly, several improvements are needed to push it forward for widespread utility, including ink formulations and optimization for in situ context. Silk fibroin inks emerge as a viable option due to the diverse range of formulations, aqueous processability, robust and tunable mechanical properties, and self-assembly via biophysical adsorption to avoid exogenous chemical or photochemical sensitizer additives, among other features. In this review, we focus on this new frontier of 3D in situ printing for tissue regeneration, where silk is proposed as candidate biomaterial ink due to the unique and useful properties of this protein polymer.

Indexed as

Biocompatible MaterialsFibroinsInkSilkAnimalsHumansPrinting, Three-DimensionalBiocompatible MaterialsFibroinsSilkinkin situ 3D printingsilk

Identifiers

PMID33279280
PMCPMC8169713

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.