Evidence map›Paper›PMID 33278710›Full record

ArticleImmunobiology2021

Myeloid arginase-1 controls excessive inflammation and modulates T cell responses in Pseudomonas aeruginosa pneumonia.

Dalia Haydar, Rene Gonzalez, Beth A Garvy, Sylvie Garneau-Tsodikova, Nishad Thamban Chandrika, Therese J Bocklage, David J Feola

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Mechanisms underlying aryl hydrocarbon receptor-driven divergent macrophage function.Toxicological sciences : an official journal of the Society of Toxicology · 2024
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dalia HaydarUniversity of Kentucky, Department of Pharmacy Practice and Science, 789 S. Limestone Street, Lexington, KY 40536, USA. Electronic address: dalia.haydar@uky.edu.
Rene GonzalezUniversity of Kentucky, Department of Pharmacy Practice and Science, 789 S. Limestone Street, Lexington, KY 40536, USA. Electronic address: rigonz87@utexas.edu.
Beth A GarvyUniversity of Kentucky, College of Medicine, Department of Microbiology, Immunology and Molecular Genetics, 800 Rose Street, Lexington, KY 40536, USA. Electronic address: beth.garvy@uky.edu.
Sylvie Garneau-TsodikovaUniversity of Kentucky, College of Pharmacy, Department of Pharmaceutical Sciences, 789 S. Limestone Street, Lexington, KY 40536, USA. Electronic address: sylviegtsodikova@uky.edu.
Nishad Thamban ChandrikaUniversity of Kentucky, College of Pharmacy, Department of Pharmaceutical Sciences, 789 S. Limestone Street, Lexington, KY 40536, USA. Electronic address: nishad.tc@uky.edu.
Therese J BocklageUniversity of Kentucky Healthcare, Pathology and Laboratory Medicine, 800 Rose Street, Lexington, KY 40536, USA. Electronic address: therese.bocklage@uky.edu.
David J FeolaUniversity of Kentucky, Department of Pharmacy Practice and Science, 789 S. Limestone Street, Lexington, KY 40536, USA. Electronic address: david.feola@uky.edu.

Funding

Alternative macrophage activation in acute Pseudomonas pneumoniaR01AI095307 · NIAID · UNIVERSITY OF KENTUCKY · PI FEOLA, DAVID · 2012 to 2016
$1.8M
NIAID NIH HHS R01 AI095307
6 · The paper itself

Abstract

Regulatory properties of macrophages associated with alternative activation serve to limit the exaggerated inflammatory response during pneumonia caused by Pseudomonas aeruginosa infection. Arginase-1 is an important effector of these macrophages believed to play an essential role in decreasing injury and promoting repair. We investigated the role of arginase-1 in the control of inflammatory immune responses to P. aeruginosa pneumonia in mice that exhibit different immunologic phenotypes. C57BL/6 mice with conditional knockout of the arginase-1 (Arg1) gene from myeloid cells (Arg1

Indexed as

AnimalsArginaseBoronic AcidsCD4-Positive T-LymphocytesCytokinesFemaleGenetic BackgroundGenetic Predisposition to DiseaseHumansImmunomodulationInflammationLungLymphocyte ActivationMacrophage ActivationMaleMice(2-boronoethyl)-cysteineArg1 protein, mouseArginaseBoronic AcidsCytokinesAlternative macrophagesArginase-1Cystic fibrosisInflammatory lung injuryNeutrophilsPneumoniaPseudomonas aeruginosa

Identifiers

PMID33278710
PMCPMC7855574

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.