ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021
Impact of low serum calcium at hospital admission on SARS-CoV-2 infection outcome.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Pooled it
- Electrolyte imbalances as poor prognostic markers in COVID-19: a systemic review and meta-analysis.Journal of endocrinological investigation · 2023Pooled it
- The effect of low serum calcium level on the severity and mortality of Covid patients: A systematic review and meta-analysis.Immunity, inflammation and disease · 2021Pooled it
- Hypocalcemia is associated with severe COVID-19: A systematic review and meta-analysis.Diabetes & metabolic syndromePooled it
- Association between serum calcium and in-hospital mortality in patients with severe fever with thrombocytopenia syndrome: a retrospective cohort study.Virology journal · 2026Article
- The association between ionized calcium level and 28-day mortality in patients with sepsis: a cohort study.Scientific reports · 2025Article
- Article
- Total network controllability analysis discovers explainable drugs for Covid-19 treatment.Biology direct · 2023Article
- Review
- Calcium, Phosphorus and Magnesium Abnormalities Associated with COVID-19 Infection, and Beyond.Biomedicines · 2023Review
- Total network controllability analysis discovers explainable drugs for Covid-19 treatment.Research square · 2023Article
- Hypocalcemia on Admission Is a Predictor of Disease Progression in COVID-19 Patients with Cirrhosis: A Multicenter Study in Hungary.Biomedicines · 2023Article
- Additive prognostic value of serum calcium to the ESC risk stratification in patients with acute pulmonary embolism.Thrombosis journal · 2023Article
- An overview on role of nutrition on COVID-19 immunity: Accumulative review from available studies.Clinical nutrition open science · 2023Review
- Calcium, phosphorus, magnesium levels in frequent respiratory tract infections.Annals of medicine · 2023Article
- Effects of nutrients on immunomodulation in patients with severe COVID-19: Current knowledge.World journal of critical care medicine · 2022Review
- Nanoantidote for repression of acidosis pH promoting COVID-19 infection.View (Beijing, China) · 2022Article
- Promising Therapeutic Approach for SARS-CoV-2 Infections by Using a Rutin-Based Combination Therapy.ChemMedChem · 2022Article
- Hypocalcemia in COVID-19: Prevalence, clinical significance and therapeutic implications.Reviews in endocrine & metabolic disorders · 2022Review
- Lower plasma calcium associated with COVID-19, but not with disease severity: a two-centre retrospective cohort study.Infectious diseases (London, England) · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCalcium is an essential ion for pathogen survival and virulence and is involved in the regulation of the inflammatory response. Hypocalcemia is a common laboratory finding in critically ill patients. Data regarding levels of calcium in SARS-CoV-2 infection is scarce. Patients with SARS-CoV-2 infection who present with hypocalcemia could have a worse outcome.
methodsWe performed a retrospective analysis of hospitalized patients with SARS-CoV-2 infection and included all patients who had any serum calcium measurement in the first 72h since hospital admission. The main objective was to investigate the relation of low serum calcium with adverse outcome, measured by the requirement of high oxygen support - defined as high flow nasal cannula oxygen, non-invasive mechanical ventilation and/or invasive ventilation - intensive care unit admission or death.
resultsA total of 316 patients were included in the study. Median age was 65 years (IQR 55-74); 65% were men. Hypocalcemia within 72h since hospital admission was present in 63% of patients. A higher number of patients in the hypocalcemia group required high oxygen support during hospitalization (49% vs 32%; p=0,01) and were admitted to the ICU (42% vs 26%; p=0,005). No differences in mortality were observed between groups.
conclusionsHypocalcemia is frequent in hospitalized patients with SARS-CoV-2 infection and can identify patients who will have a worse outcome. More studies are needed to understand the role of calcium metabolism in SARS-CoV-2 infection and to address the clinical implications and therapeutic interventions it might have.
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