Evidence map›Paper›PMID 33278521›Full record

ArticleResuscitation2021

Airway insertion first pass success and patient outcomes in adult out-of-hospital cardiac arrest: The Pragmatic Airway Resuscitation Trial.

Jason A Lesnick, Justin X Moore, Yefei Zhang, Jeffrey Jarvis, Graham Nichol, Mohamud R Daya, Ahamed H Idris, Cameron Klug, David Dennis, Jestin N Carlson and 4 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Perceived Versus Actual Time of Prehospital Intubation by Paramedics.The western journal of emergency medicine · 2024
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jason A LesnickDepartment of Emergency Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Justin X MooreDivision of Epidemiology, Department of Population Health Sciences, Augusta University, Augusta, GA, USA.
Yefei ZhangDepartment of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Jeffrey JarvisWilliamson County Emergency Medical Services, Georgetown, TX, USA; Texas A&M Health Science Center, Temple, TX, USA.
Graham NicholUniversity of Washington[HYPHEN]Harborview Center for Prehospital Emergency Care, Departments of Medicine and Emergency Medicine, University of Washington, Seattle, WA, USA.
Mohamud R DayaDepartment of Emergency Medicine, Oregon Health and Science University, Portland, OR, USA.
Ahamed H IdrisDepartment of Emergency Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Cameron KlugLegacy Meridian Park Medical Center. Tualatin, OR, USA.
David DennisTualatin Valley Fire & Rescue, Tigard, OR, USA.
Jestin N CarlsonUniversity of Pittsburgh, Pittsburgh, PA, USA; Department of Emergency Medicine, Saint Vincent Hospital, Allegheny Health Network, Erie, PA, USA.
Pratik DoshiDepartment of Emergency Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
George SopkoNational Institutes of Health, Bethesda, MD, USA.
Robert H SchmickerDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Henry E WangDepartment of Emergency Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA. Electronic address: henry.e.wang@uth.tmc.edu.

Funding

Pragmatic Trial of Airway Management in Out-of-Hospital Cardiac ArrestUH3HL125163 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KERBY, JEFFREY D, WANG, HENRY E. · 2015 to 2018
$2.7M
Pragmatic Trial of Airway Management in Out-of-Hospital Cardiac ArrestUH2HL125163 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WANG, HENRY E. · 2014 to 2014
$481k
NHLBI NIH HHS UH2 HL125163NHLBI NIH HHS UH3 HL125163
6 · The paper itself

Abstract

objectiveWhile emphasized in clinical practice, the association between advanced airway insertion first-pass success (FPS) and patient outcomes is incompletely understood. We sought to determine the association of airway insertion FPS with adult out-of-hospital cardiac arrest (OHCA) outcomes in the Pragmatic Airway Resuscitation Trial (PART).

methodsWe performed a secondary analysis of PART, a multicenter clinical trial comparing LT and ETI upon adult OHCA outcomes. We defined FPS as successful LT insertion or ETI on the first attempt as reported by EMS personnel. We examined the outcomes return of spontaneous circulation (ROSC), 72-h survival, hospital survival, and hospital survival with favorable neurologic status (Modified Rankin Scale ≤3). Using multivariable GEE (generalized estimating equations), we determined the association between FPS and OHCA outcomes, adjusting for age, sex, witnessed arrest, bystander CPR, initial rhythm, and initial airway type.

resultsOf 3004 patients enrolled in the trial, 1423 received LT, 1227 received ETI, 354 received bag-valve-mask ventilation only. FPS was: LT 86.2% and ETI 46.7%. FPS was associated with increased ROSC (aOR 1.23; 95%CI: 1.07-1.41)), but not 72-h survival (1.22; 0.94-1.58), hospital survival (0.90; 0.68-1.19) or hospital survival with favorable neurologic status (0.66; 0.37-1.19).

conclusionIn adult OHCA, airway insertion FPS was associated with increased ROSC but not other OHCA outcomes. The influence of airway insertion FPS upon OHCA outcomes is unclear.

Indexed as

Cardiopulmonary ResuscitationEmergency Medical ServicesOut-of-Hospital Cardiac ArrestAdultHumansIntubation, IntratrachealTreatment OutcomeAirway managementCardiopulmonary arrestEmergency medical servicesIntubation (intratracheal)

Identifiers

PMID33278521
PMCPMC7855546

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.