Evidence map›Paper›PMID 33278491›Full record

ArticleMolecular and cellular endocrinology2021

Thyroid dysfunction may be associated with poor outcomes in patients with COVID-19.

Yan Zhang, Fengyu Lin, Wei Tu, Jianchu Zhang, Abira Afzal Choudhry, Omair Ahmed, Jun Cheng, Yanhui Cui, Ben Liu, Minhui Dai and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 5 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 5 syntheses or guidelines pooled it, 71 citations in OpenAlex.

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  14. The relation between FTFrontiers in endocrinology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 3 countries.

Yan ZhangDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Fengyu LinDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Wei TuDivision of Allergy and Clinical Immunology, John Hopkins University School of Medicine, Baltimore, MD, 21224, USA.
Jianchu ZhangDepartment of Respiratory Medicine, Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China.
Abira Afzal ChoudhryZiauddin University, Clifton, Karachi, 75600, Pakistan.
Omair AhmedZiauddin University, Clifton, Karachi, 75600, Pakistan.
Jun ChengDepartment of Gastrointestinal Surgery& Breast& Thyroid Surgery, Changsha Hospital of Traditional Chinese Medicine, Changsha, Hunan, China.
Yanhui CuiDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Ben LiuDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Minhui DaiDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Lingli ChenDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Duoduo HanDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Yifei FanDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Yanjun ZengDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Wen LiDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Sha LiDepartment of Radiology, Xiangya Hospital, Central South University. Changsha, Hunan, 410008, China.
Xiang ChenDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Minxue ShenDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China; Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, Hunan, 410008, China. Electronic address: shenmx1988@csu.edu.cn.
Pinhua PanDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. Electronic address: pinhuapan668@csu.edu.cn.
medical team from Xiangya Hospital to support Hubei, China
Central South University · CNZiauddin University · PKHunan Academy of Traditional Chinese Medicine · CNJohns Hopkins University · USWuhan Union Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronavirus disease (COVID-19) has resulted in considerable morbidity and mortality worldwide. Thyroid hormones play a key role in modulating metabolism and the immune system. However, the prevalence of thyroid dysfunction (TD) and its association with the prognosis of COVID-19 have not yet been elucidated. In this study, we seek to address this gap and understand the link between TD and COVID-19.

methodsHerein, we enrolled patients who were hospitalized with COVID-19 and had normal or abnormal thyroid function test results at the West Court of Union Hospital in Wuhan, China, between 29 January and February 26, 2020. We carried out follow up examinations until April 26, 2020. Data on clinical features, treatment strategies, and prognosis were collected and analyzed. TD was defined as an abnormal thyroid function test result, including overt thyrotoxicosis, overt hypothyroidism, subclinical hypothyroidism, subclinical hyperthyroidism, and euthyroid sick syndrome.

resultsA total of 25 and 46 COVID-19 patients with and without TD, respectively, were included in the study. COVID-19 patients with TD had significantly higher neutrophil counts and higher levels of C-reactive protein, procalcitonin, lactate dehydrogenase, serum creatine kinase, aspartate transaminase, and high-sensitive troponin I and a longer activated partial thromboplastin time but lower lymphocyte, platelet, and eosinophil counts. A longitudinal analysis of serum biomarkers showed that patients with TD presented persistently high levels of biomarkers for inflammatory response and cardiac injury. COVID-19 patients with TD were more likely to develop a critical subtype of the disease. Patients with TD had a significantly higher fatality rate than did those without TD during hospitalization (20% vs 0%, P = 0.002). Patients with TD were more likely to stay in the hospital for more than 28 days than were those without TD (80% vs 56.52%, P = 0.048).

conclusionsOur preliminary findings suggest that TD is associated with poor outcomes in patients with COVID-19.

Indexed as

AgedChinaCOVID-19FemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesThyroid DiseasesThyroid Function TestsThyroid GlandCOVID-19PrognosisSARS-CoV-2Thyroid dysfunction

Identifiers

PMID33278491
PMCPMC7709789
OpenAlexW3108021632

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.