ArticleThe Journal of infection2021
Impact of low blood culture usage on rates of antimicrobial resistance.
Article in The Journal of infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- How to utilize routine antimicrobial resistance surveillance data for local and national actions in an LMIC.JAC-antimicrobial resistance · 2025Review
- Combining demographic shifts with age-based resistance prevalence to estimate future antimicrobial resistance burden in Europe and implications for targets: A modelling study.PLoS medicine · 2025Article
- Tools and challenges in the use of routine clinical data for antimicrobial resistance surveillance.npj antimicrobials and resistance · 2025Review
- Article
- The trends of blood culture contamination and utilization rates in an LMIC tertiary care center from 2010 to 2022: a call for diagnostic stewardship?Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Conference report of the 2024 Antimicrobial Resistance Meeting.npj antimicrobials and resistance · 2024Article
- Predicting future hospital antimicrobial resistance prevalence using machine learning.Communications medicine · 2024Article
- Frequency of antimicrobial-resistant bloodstream infections in 111 hospitals in Thailand, 2022.The Journal of infection · 2024Article
- Global burden of bacterial antimicrobial resistance 1990-2021: a systematic analysis with forecasts to 2050.Lancet (London, England) · 2024Article
- Diagnostic and antibiotic use practices among COVID-19 and non-COVID-19 patients in the Indonesian National Referral Hospital.PloS one · 2024Article
- Article
- Use and Quality of Blood Cultures for the Diagnosis of Bloodstream Infections: A Cross-Sectional Study in the Ho Teaching Hospital, Ghana, 2019-2021.International journal of environmental research and public health · 2023Article
- Estimating antibiotic coverage from linked microbiological and clinical data from the Swiss Paediatric Sepsis Study to support empiric antibiotic regimen selection.Frontiers in pediatrics · 2023Article
- Gastrointestinal Carriage of Antimicrobial Resistance in School-Aged Children in Three Municipalities of Timor-Leste.Antibiotics (Basel, Switzerland) · 2022Article
- Excess Mortality Attributable to Hospital-Acquired Antimicrobial-Resistant Infections: A 2-Year Prospective Surveillance Study in Northeast Thailand.Open forum infectious diseases · 2022Article
- Blood culture utilization and epidemiology of antimicrobial-resistant bloodstream infections before and during the COVID-19 pandemic in the Indonesian national referral hospital.Antimicrobial resistance and infection control · 2022Article
- Excess mortality attributable to antimicrobial-resistant bacterial bloodstream infection at a tertiary-care hospital in Indonesia.PLOS global public health · 2022Article
- Association Between Gut Dysbiosis and Sepsis-Induced Myocardial Dysfunction in Patients With Sepsis or Septic Shock.Frontiers in cellular and infection microbiology · 2022Observational
- A Clinically Oriented antimicrobial Resistance surveillance Network (ACORN): pilot implementation in three countries in Southeast Asia, 2019-2020.Wellcome open research · 2022Article
- Surveillance strategies using routine microbiology for antimicrobial resistance in low- and middle-income countries.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2021Review
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
objectivesThe magnitude of impact caused by low blood culture utilization on estimates of the proportions and incidence rates of antimicrobial-resistant (AMR) bacterial infections is largely unknown.
methodsWe used routine electronic databases of microbiology, hospital admission and drug prescription at Sunpasitthiprasong Hospital, Ubon Ratchathani, Thailand, from 2011 to 2015, and bootstrap simulations.
resultsThe proportions of Escherichia coli and Klebsiella pneumoniae bacteraemias caused by 3rd generation cephalosporin resistant isolates (3GCREC and 3GCRKP) were estimated to increase by 13 and 24 percentage points (from 44% to 57% and from 51% to 75%), respectively, if blood culture utilization rate was reduced from 82 to 26 blood culture specimens per 1,000 patient-days. Among patients with hospital-origin bloodstream infections, the proportion of 3GCREC and 3GCRKP whose first positive blood culture was taken within ±1 calendar day of the start of a parenteral antibiotic at the study hospital was substantially lower than those whose first positive blood culture was taken later into parenteral antibiotic treatment (30% versus 79%, p<0.001; and 37% versus 86%, p<0.001). Similar effects were observed for methicillin-resistant Staphylococcus aureus, carbapenem-resistant Acinetobacter spp. and carbapenem-resistant Pseudomonas aeruginosa.
conclusionImpacts of low blood culture utilization rate on the estimated proportions and incidence rates of AMR infections could be high. We recommend that AMR surveillance reports should additionally include blood culture utilization rate and stratification by exposure to a parenteral antibiotic at the hospital.
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