Evidence map›Paper›PMID 33278365›Full record

ArticleArchives of physical medicine and rehabilitation2021

Effect of Different Forms of Activity-Based Recovery Training on Bladder, Bowel, and Sexual Function After Spinal Cord Injury.

Charles H Hubscher, Jennifer Wyles, Anthony Gallahar, Kristen Johnson, Andrea Willhite, Susan J Harkema, April N Herrity

Open access · greenAbstract read
In one paragraph

Article in Archives of physical medicine and rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Regional Molecular Diversity in Chronic Spinal Cord Injury.Cellular and molecular neurobiology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Quality of sexual life in Mexican men after spinal cord injury.Journal of rehabilitation medicine · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Observational
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Charles H HubscherDepartment of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, KY; Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY. Electronic address: chhubs01@louisville.edu.
Jennifer WylesKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY; Department of Neurological Surgery, University of Louisville, Louisville, KY.
Anthony GallaharKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY; Department of Neurological Surgery, University of Louisville, Louisville, KY.
Kristen JohnsonKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY; Department of Neurological Surgery, University of Louisville, Louisville, KY.
Andrea WillhiteKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY; Department of Neurological Surgery, University of Louisville, Louisville, KY.
Susan J HarkemaKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY; Department of Neurological Surgery, University of Louisville, Louisville, KY.
April N HerrityKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY; Department of Neurological Surgery, University of Louisville, Louisville, KY.
University of Louisville · USNeurological Surgery · US

Funding

Effects of activity dependent plasticity on recovery of bladder and sexual function after human spinal cord injuryR01HD080205 · NICHD · UNIVERSITY OF LOUISVILLE · PI ANDREA L. BEHRMAN, CHARLES H. HUBSCHER · 2014 to 2026
$4.0M
NICHD NIH HHS R01 HD080205
6 · The paper itself

Abstract

objectivesTo investigate whether the urogenital and bowel functional gains previously demonstrated post-locomotor step training after chronic spinal cord injury could have been derived due to weight-bearing alone or from exercise in general.

designProspective cohort study; pilot trial with small sample size.

settingUrogenital and bowel scientific core facility at a rehabilitation institute and spinal cord injury research center in the United States.

participantsMen and women (N=22) with spinal cord injury (American Spinal Injury Association Impairment Scale grades of A-D) participated in this study.

interventionsApproximately 80 daily 1-hour sessions of either stand training or nonweight-bearing arm crank ergometry. Comparisons were made with previously published locomotor training data (step; N=7).

main outcome measuresAssessments at both pre- and post-training timepoints included cystometry for bladder function and International Data Set Questionnaires for bowel and sexual functions.

resultsCystometry measurements revealed a significant decrease in bladder pressure and limited improvement in compliance with nonweight-bearing exercise but not with standing. Although International Data Set questionnaires revealed profound bowel dysfunction and marked deficits in sexual function pretraining, no differences were identified poststand or after nonweight-bearing exercise.

conclusionsThese pilot trial results suggest that, although stand and weight-bearing alone do not benefit pelvic organ functions after spinal cord injury, exercise in general may contribute at least partially to the lowering of bladder pressure and the increase in compliance that was seen previously with locomotor training, potentially through metabolic, humoral, and/or cardiovascular mechanisms. Thus, to maximize activity-based recovery training benefits for functions related to storage and emptying, an appropriate level of sensory input to the spinal cord neural circuitries controlling bladder and bowel requires task-specific stepping.

Indexed as

AdultCohort StudiesExercise TherapyFemaleHumansMaleMiddle AgedNeurogenic BowelPilot ProjectsProspective StudiesRecovery of FunctionSexual Dysfunction, PhysiologicalSpinal Cord InjuriesSurveys and QuestionnairesUrinary Bladder, NeurogenicYoung AdultNeurogenic bowelPhysiologicalRehabilitationSexual dysfunctionSpinal cord injuriesUrinary bladder

Identifiers

PMID33278365
PMCPMC8084981
OpenAlexW3108410822

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.